Wound healing activity of curcuminoids:β-cyclodextrin complex nanostructures
The article is devoted to the preparation of curcuminoids with β-cyclodextrin inclusion complexes nanostructures (Cur:β-CD) and the study of its wound healing effect. Histological studies of the epidermis and dermis of skin samples obtained on the 21st day of the wound healing process on the snipped...
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2024
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ir-20.500.12258-264592024-02-15T07:46:11Z Wound healing activity of curcuminoids:β-cyclodextrin complex nanostructures Kapustin, M. А. Капустин, М. А. Piskov, S. I. Писков, С. И. Rzhepakovsky, I. V. Ржепаковский, И. В. Clathrates Snipped wound Curcumin Cyclodextrins Nanostructures Rats wistar Scarless healing Wound healing The article is devoted to the preparation of curcuminoids with β-cyclodextrin inclusion complexes nanostructures (Cur:β-CD) and the study of its wound healing effect. Histological studies of the epidermis and dermis of skin samples obtained on the 21st day of the wound healing process on the snipped wound model in Wistar rats in control without treatment, with the use of the combined antibacterial drug baneocin, with the use of β-cyclodextrin and the preparation of nanocomplexes of curcuminoids: β-cyclodextrin (1:2 M:M). By the 21st day from the moment of inflicting the skin wound, the complete closure of the defect with the regenerate, which generally has the structure of normal skin, was registered. Histologically, restoration of all layers of the epithelium is noted. The formation of single hair follicles, mainly closer to the edge of the wound, was noted. In general, the use of Cur:β-CD causes organotypic skin regeneration (scarless healing), that is, processes that restore the original structure of the skin. 2024-02-15T07:44:43Z 2024-02-15T07:44:43Z 2023 Статья Kapustin, M., Piskov, S., Rzhepakovsky, I., Chubarova, H., Antonovich, A. Wound healing activity of curcuminoids:β-cyclodextrin complex nanostructures // AIP Conference Proceedings. - 2023. - 2931 (1). - статья № 060007. - DOI: 10.1063/5.0177712 http://hdl.handle.net/20.500.12258/26459 en AIP Conference Proceedings application/pdf |
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language |
English |
topic |
Clathrates Snipped wound Curcumin Cyclodextrins Nanostructures Rats wistar Scarless healing Wound healing |
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Clathrates Snipped wound Curcumin Cyclodextrins Nanostructures Rats wistar Scarless healing Wound healing Kapustin, M. А. Капустин, М. А. Piskov, S. I. Писков, С. И. Rzhepakovsky, I. V. Ржепаковский, И. В. Wound healing activity of curcuminoids:β-cyclodextrin complex nanostructures |
description |
The article is devoted to the preparation of curcuminoids with β-cyclodextrin inclusion complexes nanostructures (Cur:β-CD) and the study of its wound healing effect. Histological studies of the epidermis and dermis of skin samples obtained on the 21st day of the wound healing process on the snipped wound model in Wistar rats in control without treatment, with the use of the combined antibacterial drug baneocin, with the use of β-cyclodextrin and the preparation of nanocomplexes of curcuminoids: β-cyclodextrin (1:2 M:M). By the 21st day from the moment of inflicting the skin wound, the complete closure of the defect with the regenerate, which generally has the structure of normal skin, was registered. Histologically, restoration of all layers of the epithelium is noted. The formation of single hair follicles, mainly closer to the edge of the wound, was noted. In general, the use of Cur:β-CD causes organotypic skin regeneration (scarless healing), that is, processes that restore the original structure of the skin. |
format |
Статья |
author |
Kapustin, M. А. Капустин, М. А. Piskov, S. I. Писков, С. И. Rzhepakovsky, I. V. Ржепаковский, И. В. |
author_facet |
Kapustin, M. А. Капустин, М. А. Piskov, S. I. Писков, С. И. Rzhepakovsky, I. V. Ржепаковский, И. В. |
author_sort |
Kapustin, M. А. |
title |
Wound healing activity of curcuminoids:β-cyclodextrin complex nanostructures |
title_short |
Wound healing activity of curcuminoids:β-cyclodextrin complex nanostructures |
title_full |
Wound healing activity of curcuminoids:β-cyclodextrin complex nanostructures |
title_fullStr |
Wound healing activity of curcuminoids:β-cyclodextrin complex nanostructures |
title_full_unstemmed |
Wound healing activity of curcuminoids:β-cyclodextrin complex nanostructures |
title_sort |
wound healing activity of curcuminoids:β-cyclodextrin complex nanostructures |
publishDate |
2024 |
url |
https://dspace.ncfu.ru/handle/20.500.12258/26459 |
work_keys_str_mv |
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