Targeted Synthesis of New 5-Phenyl-2-[(E)-Styryl]-1H-Pyrimidin-6-One Derivatives and Their Inhibitory Activity Toward SARS-CoV-2 Major (MPRO) and Papain-Like Proteases (PLPRO)
The use of the 5-phenyl-1H-pyrimidin-6-one scaffold in the search for biologically active compounds with antiviral activity based on the pyrimidin-4-one core present in endogenous substances and drugs was substantiated. The molecular activity and pharmacokinetic descriptors for styryl derivatives of...
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| Главные авторы: | , |
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| 格式: | Статья |
| 语言: | English |
| 出版: |
2024
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| 主题: | |
| 在线阅读: | https://dspace.ncfu.ru/handle/20.500.12258/26581 |
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