Oxidation of 4,6-Dimethyl-2-thioxo-1,2-dihydropyridine-3-carbonitriles with Potassium Ferricyanide: Synthesis and Molecular Docking of Bis(pyrid-2-yl) Disulfides
The reaction of 4,6-dimethyl-2-thioxo-1,2-dihydropyridin-3-carbonitriles with K3[Fe(CN)6] in an alkaline medium results in the formation of a mixture of oxidation products: bis(3-cyanopyridin-2-yl) disulfides and potassium 3-cyano-4,6-dimethylpyridine-2-sulfonates. Structure of the compounds was con...
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ir-20.500.12258-265822024-02-20T13:51:04Z Oxidation of 4,6-Dimethyl-2-thioxo-1,2-dihydropyridine-3-carbonitriles with Potassium Ferricyanide: Synthesis and Molecular Docking of Bis(pyrid-2-yl) Disulfides Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В. 2-thioxo-1,2-dihydropyridine-3-carbonitriles Antiretroviral therapy Bis(pyrid-2-yl) disulfides Cyanothioacetamide Molecular docking Oxidation of thioamides The reaction of 4,6-dimethyl-2-thioxo-1,2-dihydropyridin-3-carbonitriles with K3[Fe(CN)6] in an alkaline medium results in the formation of a mixture of oxidation products: bis(3-cyanopyridin-2-yl) disulfides and potassium 3-cyano-4,6-dimethylpyridine-2-sulfonates. Structure of the compounds was confirmed by NMR, IR spectroscopy and high-resolution mass spectrometry. According to the results of molecular docking studies, 2,2′-dithiobis(5-butyl-4,6-dimethylnicotinonitrile) exhibits affinity to the zinc finger domain of the HIV-1 p7 nucleocapsid protein binding. 2024-02-20T13:50:06Z 2024-02-20T13:50:06Z 2023 Статья Dakhno, P.G., Kindop, V.K., Gordeev, K.V., Zimmer, I.A., Dotsenko, V.V., Temerdashev, A.Z., Vasilin, V.K., Aksenov, N.A., Aksenova, I.V. Oxidation of 4,6-Dimethyl-2-thioxo-1,2-dihydropyridine-3-carbonitriles with Potassium Ferricyanide: Synthesis and Molecular Docking of Bis(pyrid-2-yl) Disulfides // Russian Journal of General Chemistry. - 2023. - 93 (12). - pp. 3043-3054. - DOI: 10.1134/S1070363223120034 http://hdl.handle.net/20.500.12258/26582 en Russian Journal of General Chemistry application/pdf application/pdf |
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| language |
English |
| topic |
2-thioxo-1,2-dihydropyridine-3-carbonitriles Antiretroviral therapy Bis(pyrid-2-yl) disulfides Cyanothioacetamide Molecular docking Oxidation of thioamides |
| spellingShingle |
2-thioxo-1,2-dihydropyridine-3-carbonitriles Antiretroviral therapy Bis(pyrid-2-yl) disulfides Cyanothioacetamide Molecular docking Oxidation of thioamides Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В. Oxidation of 4,6-Dimethyl-2-thioxo-1,2-dihydropyridine-3-carbonitriles with Potassium Ferricyanide: Synthesis and Molecular Docking of Bis(pyrid-2-yl) Disulfides |
| description |
The reaction of 4,6-dimethyl-2-thioxo-1,2-dihydropyridin-3-carbonitriles with K3[Fe(CN)6] in an alkaline medium results in the formation of a mixture of oxidation products: bis(3-cyanopyridin-2-yl) disulfides and potassium 3-cyano-4,6-dimethylpyridine-2-sulfonates. Structure of the compounds was confirmed by NMR, IR spectroscopy and high-resolution mass spectrometry. According to the results of molecular docking studies, 2,2′-dithiobis(5-butyl-4,6-dimethylnicotinonitrile) exhibits affinity to the zinc finger domain of the HIV-1 p7 nucleocapsid protein binding. |
| format |
Статья |
| author |
Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В. |
| author_facet |
Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В. |
| author_sort |
Dotsenko, V. V. |
| title |
Oxidation of 4,6-Dimethyl-2-thioxo-1,2-dihydropyridine-3-carbonitriles with Potassium Ferricyanide: Synthesis and Molecular Docking of Bis(pyrid-2-yl) Disulfides |
| title_short |
Oxidation of 4,6-Dimethyl-2-thioxo-1,2-dihydropyridine-3-carbonitriles with Potassium Ferricyanide: Synthesis and Molecular Docking of Bis(pyrid-2-yl) Disulfides |
| title_full |
Oxidation of 4,6-Dimethyl-2-thioxo-1,2-dihydropyridine-3-carbonitriles with Potassium Ferricyanide: Synthesis and Molecular Docking of Bis(pyrid-2-yl) Disulfides |
| title_fullStr |
Oxidation of 4,6-Dimethyl-2-thioxo-1,2-dihydropyridine-3-carbonitriles with Potassium Ferricyanide: Synthesis and Molecular Docking of Bis(pyrid-2-yl) Disulfides |
| title_full_unstemmed |
Oxidation of 4,6-Dimethyl-2-thioxo-1,2-dihydropyridine-3-carbonitriles with Potassium Ferricyanide: Synthesis and Molecular Docking of Bis(pyrid-2-yl) Disulfides |
| title_sort |
oxidation of 4,6-dimethyl-2-thioxo-1,2-dihydropyridine-3-carbonitriles with potassium ferricyanide: synthesis and molecular docking of bis(pyrid-2-yl) disulfides |
| publishDate |
2024 |
| url |
https://dspace.ncfu.ru/handle/20.500.12258/26582 |
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