Analgesic activity of new derivatives of quinazolinone-4

In the of study was investigated the antinociceptive action of derivatives of quinazolinone-4 in 187 male and 196 female rats, including females rats in the different stages of the estrous cycle: diestrus 1/2 and proestrus /estrus in models of nociceptive responses induced by chemical stimuli (forma...

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Principais autores:	Manvelyan, E. A., Манвелян, Э. А., Manvelyan, M. M., Манвелян, М. М.
Formato:	Статья
Idioma:	English
Publicado em:	Stavropol State Medical University 2018
Assuntos:	Acetic cramps Analgesic effect Derivatives of quinazolinone-4 Formalin test
Acesso em linha:	https://www.scopus.com/record/display.uri?eid=2-s2.0-85034623957&origin=resultslist&sort=plf-f&src=s&nlo=&nlr=&nls=&sid=d6548cad91c5314e6f0f72c342496650&sot=aff&sdt=sisr&sl=145&s=AF-ID%28%22North+Caucasus+Federal+University%22+60070541%29+OR+AF-ID%28%22%5bNo+Affiliation+ID+found%5d%22+60070961%29+OR+AF-ID%28%22%5bNo+Affiliation+ID+found%5d%22+60026323%29&ref=%28Analgesic+activity+of+new+derivatives+of+quinazolinone-4%29&relpos=0&citeCnt=0&searchTerm= https://dspace.ncfu.ru/handle/20.500.12258/2690
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spelling	ir-20.500.12258-26902020-07-06T13:53:03Z Analgesic activity of new derivatives of quinazolinone-4 Manvelyan, E. A. Манвелян, Э. А. Manvelyan, M. M. Манвелян, М. М. Acetic cramps Analgesic effect Derivatives of quinazolinone-4 Formalin test In the of study was investigated the antinociceptive action of derivatives of quinazolinone-4 in 187 male and 196 female rats, including females rats in the different stages of the estrous cycle: diestrus 1/2 and proestrus /estrus in models of nociceptive responses induced by chemical stimuli (formalin test, « acetic cramps» ), to assess the level of organization of the peripheral pain sensation. Substances (laboratory code numbers: PGFA - I, II, III, IV, V, VI, VII) at a dose of 2/10 of the molecular weight in mg/kg, reference drugs: metamizole sodium and lidocaine was administered once intraperitoneally 40 minutes before administration of chemical irritants. Control and males received respectively solubilizate Tween-80 and saline (0.4 ml intraperitoneally) under similar conditions. The 4-quinazolinone derivatives compounds I-IV, VI, VII were investigated as potential analgesics. Substance I-IV, VI, VII exhibited analgesic activity in male and female rats. Substances I, VI, VII have analgesic effects on female rats in phase of the estrous cycle diestrus 54; substance I-IV, VI - in the stage of proestrus/estrus. Among the investigated derivatives of quinazolinone-4 compound VI is a leader in analgesic activity 2018-08-01T13:54:27Z 2018-08-01T13:54:27Z 2017 Статья Manvelyan, E.A., Manvelyan, M.M., Codonidi, I.P., Oganesyan, E.T. Analgesic activity of new derivatives of quinazolinone-4 // Medical News of North Caucasus. - 2017. - Volume 12. - Issue 3. - Pages 307-311 https://www.scopus.com/record/display.uri?eid=2-s2.0-85034623957&origin=resultslist&sort=plf-f&src=s&nlo=&nlr=&nls=&sid=d6548cad91c5314e6f0f72c342496650&sot=aff&sdt=sisr&sl=145&s=AF-ID%28%22North+Caucasus+Federal+University%22+60070541%29+OR+AF-ID%28%22%5bNo+Affiliation+ID+found%5d%22+60070961%29+OR+AF-ID%28%22%5bNo+Affiliation+ID+found%5d%22+60026323%29&ref=%28Analgesic+activity+of+new+derivatives+of+quinazolinone-4%29&relpos=0&citeCnt=0&searchTerm= http://hdl.handle.net/20.500.12258/2690 en Medical News of North Caucasus application/pdf Stavropol State Medical University
institution	СКФУ
collection	Репозиторий
language	English
topic	Acetic cramps Analgesic effect Derivatives of quinazolinone-4 Formalin test
spellingShingle	Acetic cramps Analgesic effect Derivatives of quinazolinone-4 Formalin test Manvelyan, E. A. Манвелян, Э. А. Manvelyan, M. M. Манвелян, М. М. Analgesic activity of new derivatives of quinazolinone-4
description	In the of study was investigated the antinociceptive action of derivatives of quinazolinone-4 in 187 male and 196 female rats, including females rats in the different stages of the estrous cycle: diestrus 1/2 and proestrus /estrus in models of nociceptive responses induced by chemical stimuli (formalin test, « acetic cramps» ), to assess the level of organization of the peripheral pain sensation. Substances (laboratory code numbers: PGFA - I, II, III, IV, V, VI, VII) at a dose of 2/10 of the molecular weight in mg/kg, reference drugs: metamizole sodium and lidocaine was administered once intraperitoneally 40 minutes before administration of chemical irritants. Control and males received respectively solubilizate Tween-80 and saline (0.4 ml intraperitoneally) under similar conditions. The 4-quinazolinone derivatives compounds I-IV, VI, VII were investigated as potential analgesics. Substance I-IV, VI, VII exhibited analgesic activity in male and female rats. Substances I, VI, VII have analgesic effects on female rats in phase of the estrous cycle diestrus 54; substance I-IV, VI - in the stage of proestrus/estrus. Among the investigated derivatives of quinazolinone-4 compound VI is a leader in analgesic activity
format	Статья
author	Manvelyan, E. A. Манвелян, Э. А. Manvelyan, M. M. Манвелян, М. М.
author_facet	Manvelyan, E. A. Манвелян, Э. А. Manvelyan, M. M. Манвелян, М. М.
author_sort	Manvelyan, E. A.
title	Analgesic activity of new derivatives of quinazolinone-4
title_short	Analgesic activity of new derivatives of quinazolinone-4
title_full	Analgesic activity of new derivatives of quinazolinone-4
title_fullStr	Analgesic activity of new derivatives of quinazolinone-4
title_full_unstemmed	Analgesic activity of new derivatives of quinazolinone-4
title_sort	analgesic activity of new derivatives of quinazolinone-4
publisher	Stavropol State Medical University
publishDate	2018
url	https://www.scopus.com/record/display.uri?eid=2-s2.0-85034623957&origin=resultslist&sort=plf-f&src=s&nlo=&nlr=&nls=&sid=d6548cad91c5314e6f0f72c342496650&sot=aff&sdt=sisr&sl=145&s=AF-ID%28%22North+Caucasus+Federal+University%22+60070541%29+OR+AF-ID%28%22%5bNo+Affiliation+ID+found%5d%22+60070961%29+OR+AF-ID%28%22%5bNo+Affiliation+ID+found%5d%22+60026323%29&ref=%28Analgesic+activity+of+new+derivatives+of+quinazolinone-4%29&relpos=0&citeCnt=0&searchTerm= https://dspace.ncfu.ru/handle/20.500.12258/2690
work_keys_str_mv	AT manvelyanea analgesicactivityofnewderivativesofquinazolinone4 AT manvelânéa analgesicactivityofnewderivativesofquinazolinone4 AT manvelyanmm analgesicactivityofnewderivativesofquinazolinone4 AT manvelânmm analgesicactivityofnewderivativesofquinazolinone4
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Analgesic activity of new derivatives of quinazolinone-4

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