Synthesis of thiazolo[3,2-a]pyridines via an unusual Mannich-type cyclization
The Mannich-type reaction of N-methylmorpholinium 4-aryl-3-cyano-6-oxo-1,4,5,6-tetrahydropyridine-2-thiolates with 3-(1,3-benzodioxol-5-yl)-2-methylpropanal (ocean propanal) and p-toluidine afforded 7-aryl-2-(1,3-benzodioxol-5-ylmethyl)-2-methyl-3-[(4-methylphenyl)amino]-5-oxo-2,3,6,7-tetrahydro-5H-...
में बचाया:
| मुख्य लेखकों: | , |
|---|---|
| स्वरूप: | Статья |
| भाषा: | English |
| प्रकाशित: |
Taylor and Francis Ltd.
2018
|
| विषय: | |
| ऑनलाइन पहुंच: | https://www.scopus.com/record/display.uri?eid=2-s2.0-84992129583&origin=resultslist&sort=plf-f&src=s&st1=Synthesis+of+thiazolo%5b3%2c2-a%5dpyridines+via+an+unusual+Mannich-type+cyclization&st2=&sid=60eedcc0553c9716e061af579858b0e1&sot=b&sdt=b&sl=92&s=TITLE-ABS-KEY%28Synthesis+of+thiazolo%5b3%2c2-a%5dpyridines+via+an+unusual+Mannich-type+cyclization%29&relpos=0&citeCnt=3&searchTerm= https://dspace.ncfu.ru/handle/20.500.12258/3077 |
| टैग : |
टैग जोड़ें
कोई टैग नहीं, इस रिकॉर्ड को टैग करने वाले पहले व्यक्ति बनें!
|
| सारांश: | The Mannich-type reaction of N-methylmorpholinium 4-aryl-3-cyano-6-oxo-1,4,5,6-tetrahydropyridine-2-thiolates with 3-(1,3-benzodioxol-5-yl)-2-methylpropanal (ocean propanal) and p-toluidine afforded 7-aryl-2-(1,3-benzodioxol-5-ylmethyl)-2-methyl-3-[(4-methylphenyl)amino]-5-oxo-2,3,6,7-tetrahydro-5H-thiazolo[3,2-a]pyridine-8-carbonitriles in modest (25–46%) yields. The structure of the key compound was confirmed by X-ray crystal structure analysis |
|---|