5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells

Plants of the Amaryllidaceae family produce a large variety of alkaloids and non-basic secondary metabolites, many of which are investigated for their promising anticancer activities. Of these, crinine-type alkaloids based on the 5,10b-ethanophenanthridine ring system were recently shown to be effec...

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Главные авторы:	Aksenov, A. V., Аксенов, А. В.
Формат:	Статья
Язык:	English
Опубликовано:	Elsevier Masson SAS 2018
Темы:	Apoptosis resistance Glioblastoma Multidrug resistance Translation inhibition
Online-ссылка:	https://dspace.ncfu.ru/handle/20.500.12258/3187
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spelling	ir-20.500.12258-31872025-02-13T12:24:06Z 5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells Aksenov, A. V. Аксенов, А. В. Apoptosis resistance Glioblastoma Multidrug resistance Translation inhibition Plants of the Amaryllidaceae family produce a large variety of alkaloids and non-basic secondary metabolites, many of which are investigated for their promising anticancer activities. Of these, crinine-type alkaloids based on the 5,10b-ethanophenanthridine ring system were recently shown to be effective at inhibiting proliferation of cancer cells resistant to various pro-apoptotic stimuli and representing tumors with dismal prognoses refractory to current chemotherapy, such as glioma, melanoma, non-small-cell lung, esophageal, head and neck cancers, among others. Using this discovery as a starting point and taking advantage of a concise biomimetic route to the crinine skeleton, a collection of crinine analogues were synthetically prepared and evaluated against cancer cells. The compounds exhibited single-digit micromolar activities and retained this activity in a variety of drug-resistant cancer cell cultures. This investigation resulted in the discovery of new bicyclic ring systems with significant potential in the development of effective clinical cancer drugs capable of overcoming cancer chemotherapy resistance 2018-10-10T13:27:14Z 2018-10-10T13:27:14Z 2016 Статья Henry, S., Kidner, R., Reisenauer, M.R., Magedov, I.V., Kiss, R., Mathieu, V., Lefranc, F., Dasari, R., Evidente, A., Yu, X., Ma, X., Pertsemlidis, A., Cencic, R., Pelletier, J., Cavazos, D.A., Brenner, A.J., Aksenov, A.V., Rogelj, S., Kornienko, A., Frolova, L.V. 5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells // European Journal of Medicinal Chemistry. - 2016. - Volume 120. - Pages 313-328 http://hdl.handle.net/20.500.12258/3187 en European Journal of Medicinal Chemistry application/pdf application/pdf Elsevier Masson SAS
institution	СКФУ
collection	Репозиторий
language	English
topic	Apoptosis resistance Glioblastoma Multidrug resistance Translation inhibition
spellingShingle	Apoptosis resistance Glioblastoma Multidrug resistance Translation inhibition Aksenov, A. V. Аксенов, А. В. 5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells
description	Plants of the Amaryllidaceae family produce a large variety of alkaloids and non-basic secondary metabolites, many of which are investigated for their promising anticancer activities. Of these, crinine-type alkaloids based on the 5,10b-ethanophenanthridine ring system were recently shown to be effective at inhibiting proliferation of cancer cells resistant to various pro-apoptotic stimuli and representing tumors with dismal prognoses refractory to current chemotherapy, such as glioma, melanoma, non-small-cell lung, esophageal, head and neck cancers, among others. Using this discovery as a starting point and taking advantage of a concise biomimetic route to the crinine skeleton, a collection of crinine analogues were synthetically prepared and evaluated against cancer cells. The compounds exhibited single-digit micromolar activities and retained this activity in a variety of drug-resistant cancer cell cultures. This investigation resulted in the discovery of new bicyclic ring systems with significant potential in the development of effective clinical cancer drugs capable of overcoming cancer chemotherapy resistance
format	Статья
author	Aksenov, A. V. Аксенов, А. В.
author_facet	Aksenov, A. V. Аксенов, А. В.
author_sort	Aksenov, A. V.
title	5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells
title_short	5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells
title_full	5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells
title_fullStr	5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells
title_full_unstemmed	5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells
title_sort	5,10b-ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells
publisher	Elsevier Masson SAS
publishDate	2018
url	https://dspace.ncfu.ru/handle/20.500.12258/3187
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5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells

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