Templated assembly of medium cyclic ethers: Via exo-trig nucleophilic cyclization of cyclopropenes
A novel method for the assembly of medium heterocycles via an intramolecular nucleophilic addition to cyclopropenes generated in situ from the corresponding bromocyclopropanes is described. The exo-trig nucleophilic cyclizations were shown to proceed very efficiently and in a highly diastereoselecti...
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| Médium: | Статья |
| Jazyk: | English |
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Royal Society of Chemistry
2018
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| On-line přístup: | https://www.scopus.com/record/display.uri?eid=2-s2.0-84973355637&origin=resultslist&sort=plf-f&src=s&nlo=1&nlr=20&nls=afprfnm-t&affilName=north+caucasus+federal+university&sid=0c7868cbb3df866f3fd416a84ccbeea5&sot=afnl&sdt=sisr&cluster=scopubyr%2c%222016%22%2ct&sl=53&s=%28AF-ID%28%22North+Caucasus+Federal+University%22+60070541%29%29&ref=%28Templated+assembly+of+medium+cyclic+ethers%3a+Via+exo-trig+nucleophilic+cyclization+of+cyclopropenes%29&relpos=1&citeCnt=5&searchTerm= https://dspace.ncfu.ru/handle/20.500.12258/3419 |
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| Shrnutí: | A novel method for the assembly of medium heterocycles via an intramolecular nucleophilic addition to cyclopropenes generated in situ from the corresponding bromocyclopropanes is described. The exo-trig nucleophilic cyclizations were shown to proceed very efficiently and in a highly diastereoselective fashion affording cis-fused bicyclic products possessing 7 to 10-membered medium rings; starting from a diastereomeric mixtures of bromocyclopropanes |
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