Activity of 2-aryl-2-(3-indolyl)acetohydroxamates against drug-resistant cancer cells

Many types of tumor, including glioma, melanoma, non-small cell lung, esophageal, and head and neck cancer, among others, are intrinsically resistant to apoptosis induction and poorly responsive to current therapies with proapoptotic agents. In addition, tumors often develop multidrug resistance bas...

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Главные авторы:	Aksenov, A. V., Аксенов, А. В., Smirnov, A. N., Смирнов, А. Н., Aksenov, N. A., Аксенов, Н. А., Aksenova, I. V., Аксенова, И. В.
Формат:	Статья
Язык:	English
Опубликовано:	American Chemical Society 2018
Темы:	2 aryl 2 (3 indolyl)acetohydroxamate derivative Acetohydroxamic acid Antineoplastic agent Unclassified drug Hydroxamic acid Indole derivative
Online-ссылка:	https://dspace.ncfu.ru/handle/20.500.12258/3725
Метки:	Добавить метку Нет меток, Требуется 1-ая метка записи!

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spelling	ir-20.500.12258-37252025-02-13T08:46:52Z Activity of 2-aryl-2-(3-indolyl)acetohydroxamates against drug-resistant cancer cells Aksenov, A. V. Аксенов, А. В. Smirnov, A. N. Смирнов, А. Н. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В. 2 aryl 2 (3 indolyl)acetohydroxamate derivative Acetohydroxamic acid Antineoplastic agent Unclassified drug Antineoplastic agent Hydroxamic acid Indole derivative Many types of tumor, including glioma, melanoma, non-small cell lung, esophageal, and head and neck cancer, among others, are intrinsically resistant to apoptosis induction and poorly responsive to current therapies with proapoptotic agents. In addition, tumors often develop multidrug resistance based on the cellular efflux of chemotherapeutic agents. Thus, novel anticancer agents capable of overcoming these intrinsic or developed tumor resistance mechanisms are urgently needed. We describe a series of 2-aryl-2-(3-indolyl)acetohydroxamic acids that are active against apoptosis-and multidrug-resistant cancer cells as well as glioblastoma neurosphere stemlike cell cultures derived from patients. Thus, the described compounds serve as a novel chemical scaffold for the development of potentially highly effective clinical cancer drugs 2018-12-19T14:47:52Z 2018-12-19T14:47:52Z 2015 Статья Aksenov, A.V., Smirnov, A.N., Magedov, I.V., Reisenauer, M.R., Aksenov, N.A., Aksenova, I.V., Pendleton, A.L., Nguyen, G., Johnston, R.K., Rubin, M., De Carvalho, A., Kiss, R., Mathieu, V., Lefranc, F., Correa, J., Cavazos, D.A., Brenner, A.J., Bryan, B.A., Rogelj, S., Kornienko, A., Frolova, L.V. Activity of 2-aryl-2-(3-indolyl)acetohydroxamates against drug-resistant cancer cells // Journal of Medicinal Chemistry. - 2015. - Volume 58. - Issue 5. - Pages 2206-2220 http://hdl.handle.net/20.500.12258/3725 en Journal of Medicinal Chemistry application/pdf application/pdf American Chemical Society
institution	СКФУ
collection	Репозиторий
language	English
topic	2 aryl 2 (3 indolyl)acetohydroxamate derivative Acetohydroxamic acid Antineoplastic agent Unclassified drug Antineoplastic agent Hydroxamic acid Indole derivative
spellingShingle	2 aryl 2 (3 indolyl)acetohydroxamate derivative Acetohydroxamic acid Antineoplastic agent Unclassified drug Antineoplastic agent Hydroxamic acid Indole derivative Aksenov, A. V. Аксенов, А. В. Smirnov, A. N. Смирнов, А. Н. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В. Activity of 2-aryl-2-(3-indolyl)acetohydroxamates against drug-resistant cancer cells
description	Many types of tumor, including glioma, melanoma, non-small cell lung, esophageal, and head and neck cancer, among others, are intrinsically resistant to apoptosis induction and poorly responsive to current therapies with proapoptotic agents. In addition, tumors often develop multidrug resistance based on the cellular efflux of chemotherapeutic agents. Thus, novel anticancer agents capable of overcoming these intrinsic or developed tumor resistance mechanisms are urgently needed. We describe a series of 2-aryl-2-(3-indolyl)acetohydroxamic acids that are active against apoptosis-and multidrug-resistant cancer cells as well as glioblastoma neurosphere stemlike cell cultures derived from patients. Thus, the described compounds serve as a novel chemical scaffold for the development of potentially highly effective clinical cancer drugs
format	Статья
author	Aksenov, A. V. Аксенов, А. В. Smirnov, A. N. Смирнов, А. Н. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В.
author_facet	Aksenov, A. V. Аксенов, А. В. Smirnov, A. N. Смирнов, А. Н. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В.
author_sort	Aksenov, A. V.
title	Activity of 2-aryl-2-(3-indolyl)acetohydroxamates against drug-resistant cancer cells
title_short	Activity of 2-aryl-2-(3-indolyl)acetohydroxamates against drug-resistant cancer cells
title_full	Activity of 2-aryl-2-(3-indolyl)acetohydroxamates against drug-resistant cancer cells
title_fullStr	Activity of 2-aryl-2-(3-indolyl)acetohydroxamates against drug-resistant cancer cells
title_full_unstemmed	Activity of 2-aryl-2-(3-indolyl)acetohydroxamates against drug-resistant cancer cells
title_sort	activity of 2-aryl-2-(3-indolyl)acetohydroxamates against drug-resistant cancer cells
publisher	American Chemical Society
publishDate	2018
url	https://dspace.ncfu.ru/handle/20.500.12258/3725
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Activity of 2-aryl-2-(3-indolyl)acetohydroxamates against drug-resistant cancer cells

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