Mn-mediated sequential three-component domino Knoevenagel/cyclization/Michael addition/oxidative cyclization reaction towards annulated imidazo[1,2-a]pyridines
The sequential three-component reaction between o-hydroxybenzaldehydes, N-(cyanomethyl)pyridinium salts and a nucleophile towards substituted chromenoimidazopyridines under oxidative conditions has been developed. The employment of Mn(OAc)3•2H2O or KMnO4 as stoichiometric oxidants allowed the use of...
Gardado en:
| Главные авторы: | , |
|---|---|
| Formato: | Статья |
| Idioma: | English |
| Publicado: |
Beilstein-Institut Zur Forderung der Chemischen Wissenschaften
2019
|
| Темы: | |
| Acceso en liña: | https://www.scopus.com/record/display.uri?eid=2-s2.0-85060028875&origin=resultslist&sort=plf-f&src=s&st1=Mn-mediated+sequential+three-component+domino+Knoevenagel%2fcyclization%2fMichael+addition%2foxidative+cyclization+reaction+towards+annulated+&st2=&sid=8d7e07296752d7d15dcd167d2eba731c&sot=b&sdt=b&sl=151&s=TITLE-ABS-KEY%28Mn-mediated+sequential+three-component+domino+Knoevenagel%2fcyclization%2fMichael+addition%2foxidative+cyclization+reaction+towards+annulated+%29&relpos=0&citeCnt=0&searchTerm= https://dspace.ncfu.ru/handle/20.500.12258/4192 |
| Метки: |
Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!
|
| Краткое описание: | The sequential three-component reaction between o-hydroxybenzaldehydes, N-(cyanomethyl)pyridinium salts and a nucleophile towards substituted chromenoimidazopyridines under oxidative conditions has been developed. The employment of Mn(OAc)3•2H2O or KMnO4 as stoichiometric oxidants allowed the use of a wide range of nucleophiles, such as nitromethane, (aza)indoles, pyrroles, phenols, pyrazole, indazole and diethyl malonate. The formation of the target compounds presumably proceeds through a domino Knoevenagel/cyclization/Michael addition/oxidative cyclization reaction sequence |
|---|