Chemistry and biology of ophiobolin A and its congeners
Ophiobolin A is a fungal secondary metabolite that was found to have significant activity against apoptosis-resistant glioblastoma cells through the induction of a non-apoptotic cell death, offering an innovative strategy to combat this aggressive cancer. The current article aims to make the bridge...
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| 主要な著者: | , |
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| フォーマット: | Статья |
| 言語: | English |
| 出版事項: |
Elsevier Ltd
2019
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| 主題: | |
| オンライン･アクセス: | https://www.scopus.com/record/display.uri?eid=2-s2.0-85061341873&origin=resultslist&sort=plf-f&src=s&st1=Chemistry+and+biology+of+ophiobolin+A+and+its+congeners&st2=&sid=db77b7f7f1a51320d2d80165480375cc&sot=b&sdt=b&sl=70&s=TITLE-ABS-KEY%28Chemistry+and+biology+of+ophiobolin+A+and+its+congeners%29&relpos=0&citeCnt=0&searchTerm=# https://dspace.ncfu.ru/handle/20.500.12258/4471 |
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| 要約: | Ophiobolin A is a fungal secondary metabolite that was found to have significant activity against apoptosis-resistant glioblastoma cells through the induction of a non-apoptotic cell death, offering an innovative strategy to combat this aggressive cancer. The current article aims to make the bridge between the anti-cancer effects of ophiobolin A and its unique reaction with primary amines and suggests that pyrrolylation of lysine residues on its intracellular target protein(s) and/or phosphatidylethanolamine lipid is responsible for its biological effects. The article also discusses chemical derivatization of ophiobolin A to establish first synthetically generated structure-activity relationship. Finally, the reported total synthesis efforts toward the ophiobolin class of sesterterpenes are discussed and identified as a fertile area for improvement in pursuit of these molecules as anticancer agents |
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