Chemistry and biology of ophiobolin A and its congeners

Ophiobolin A is a fungal secondary metabolite that was found to have significant activity against apoptosis-resistant glioblastoma cells through the induction of a non-apoptotic cell death, offering an innovative strategy to combat this aggressive cancer. The current article aims to make the bridge...

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Asıl Yazarlar:	Kornienko, A. V., Корниенко, А. В.
Materyal Türü:	Статья
Dil:	English
Baskı/Yayın Bilgisi:	Elsevier Ltd 2019
Konular:	Anticancer activity Apoptosis resistance Glioblastoma Ophiobolin A Sesterterpenes
Online Erişim:	https://www.scopus.com/record/display.uri?eid=2-s2.0-85061341873&origin=resultslist&sort=plf-f&src=s&st1=Chemistry+and+biology+of+ophiobolin+A+and+its+congeners&st2=&sid=db77b7f7f1a51320d2d80165480375cc&sot=b&sdt=b&sl=70&s=TITLE-ABS-KEY%28Chemistry+and+biology+of+ophiobolin+A+and+its+congeners%29&relpos=0&citeCnt=0&searchTerm=# https://dspace.ncfu.ru/handle/20.500.12258/4471
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spelling	ir-20.500.12258-44712019-03-19T10:13:26Z Chemistry and biology of ophiobolin A and its congeners Kornienko, A. V. Корниенко, А. В. Anticancer activity Apoptosis resistance Glioblastoma Ophiobolin A Sesterterpenes Ophiobolin A is a fungal secondary metabolite that was found to have significant activity against apoptosis-resistant glioblastoma cells through the induction of a non-apoptotic cell death, offering an innovative strategy to combat this aggressive cancer. The current article aims to make the bridge between the anti-cancer effects of ophiobolin A and its unique reaction with primary amines and suggests that pyrrolylation of lysine residues on its intracellular target protein(s) and/or phosphatidylethanolamine lipid is responsible for its biological effects. The article also discusses chemical derivatization of ophiobolin A to establish first synthetically generated structure-activity relationship. Finally, the reported total synthesis efforts toward the ophiobolin class of sesterterpenes are discussed and identified as a fertile area for improvement in pursuit of these molecules as anticancer agents 2019-02-25T12:29:22Z 2019-02-25T12:29:22Z 2019 Статья Masi, M., Dasari, R., Evidente, A., Mathieu, V., Kornienko, A. Chemistry and biology of ophiobolin A and its congeners // Bioorganic and Medicinal Chemistry Letters. - 2019 https://www.scopus.com/record/display.uri?eid=2-s2.0-85061341873&origin=resultslist&sort=plf-f&src=s&st1=Chemistry+and+biology+of+ophiobolin+A+and+its+congeners&st2=&sid=db77b7f7f1a51320d2d80165480375cc&sot=b&sdt=b&sl=70&s=TITLE-ABS-KEY%28Chemistry+and+biology+of+ophiobolin+A+and+its+congeners%29&relpos=0&citeCnt=0&searchTerm=# http://hdl.handle.net/20.500.12258/4471 en Bioorganic and Medicinal Chemistry Letters application/pdf application/pdf Elsevier Ltd
institution	СКФУ
collection	Репозиторий
language	English
topic	Anticancer activity Apoptosis resistance Glioblastoma Ophiobolin A Sesterterpenes
spellingShingle	Anticancer activity Apoptosis resistance Glioblastoma Ophiobolin A Sesterterpenes Kornienko, A. V. Корниенко, А. В. Chemistry and biology of ophiobolin A and its congeners
description	Ophiobolin A is a fungal secondary metabolite that was found to have significant activity against apoptosis-resistant glioblastoma cells through the induction of a non-apoptotic cell death, offering an innovative strategy to combat this aggressive cancer. The current article aims to make the bridge between the anti-cancer effects of ophiobolin A and its unique reaction with primary amines and suggests that pyrrolylation of lysine residues on its intracellular target protein(s) and/or phosphatidylethanolamine lipid is responsible for its biological effects. The article also discusses chemical derivatization of ophiobolin A to establish first synthetically generated structure-activity relationship. Finally, the reported total synthesis efforts toward the ophiobolin class of sesterterpenes are discussed and identified as a fertile area for improvement in pursuit of these molecules as anticancer agents
format	Статья
author	Kornienko, A. V. Корниенко, А. В.
author_facet	Kornienko, A. V. Корниенко, А. В.
author_sort	Kornienko, A. V.
title	Chemistry and biology of ophiobolin A and its congeners
title_short	Chemistry and biology of ophiobolin A and its congeners
title_full	Chemistry and biology of ophiobolin A and its congeners
title_fullStr	Chemistry and biology of ophiobolin A and its congeners
title_full_unstemmed	Chemistry and biology of ophiobolin A and its congeners
title_sort	chemistry and biology of ophiobolin a and its congeners
publisher	Elsevier Ltd
publishDate	2019
url	https://www.scopus.com/record/display.uri?eid=2-s2.0-85061341873&origin=resultslist&sort=plf-f&src=s&st1=Chemistry+and+biology+of+ophiobolin+A+and+its+congeners&st2=&sid=db77b7f7f1a51320d2d80165480375cc&sot=b&sdt=b&sl=70&s=TITLE-ABS-KEY%28Chemistry+and+biology+of+ophiobolin+A+and+its+congeners%29&relpos=0&citeCnt=0&searchTerm=# https://dspace.ncfu.ru/handle/20.500.12258/4471
work_keys_str_mv	AT kornienkoav chemistryandbiologyofophiobolinaanditscongeners AT kornienkoav chemistryandbiologyofophiobolinaanditscongeners
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Chemistry and biology of ophiobolin A and its congeners

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