Electrophilic activation of nitroalkanes in efficient synthesis of 1,3,4-oxadiazoles

Electrophilic activation of nitroalkanes in efficient synthesis of 1,3,4-oxadiazoles

A novel methodology for general and chemoselective preparation of non-symmetric 1,3,4-oxadiazoles is developed. This unusual reaction proceeds via polyphosphoric acid-assisted activation of nitroalkanes towards nucleophilic attack with acylhydrazides

Wedi'i Gadw mewn:

Manylion Llyfryddiaeth
Prif Awduron:	Aksenov, A. V., Аксенов, А. В., Khamraev, V. F., Хамраев, В. Ф., Aksenov, N. A., Аксенов, Н. А., Kirilov, N. K., Кирилов, Н. К., Rubin, M. A., Рубин, М. А.
Fformat:	Статья
Iaith:	English
Cyhoeddwyd:	Royal Society of Chemistry 2019
Pynciau:	1 ,3 ,4-oxadiazoles Chemoselective Efficient synthesis Electrophilic activation Nitroalkanes Novel methodology Nucleophilic attack Polyphosphoric acids
Mynediad Ar-lein:	https://dspace.ncfu.ru/handle/20.500.12258/5060
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg

Electrophilically activated nitroalkanes in the synthesis of substituted 1,3,4-oxadiazoles from amino acid derivatives
gan: Aksenov, A. V., et al.
Cyhoeddwyd: (2022)

Preparation of 1,3,4-oxadiazoles and 1,3,4-thiadiazoles via chemoselective сyclocondensation of electrophilically activated nitroalkanes to (thio)semicarbazides or thiohydrazides
gan: Aksenov, N. A., et al.
Cyhoeddwyd: (2020)

Electrophilically activated nitroalkanes in double annulation of [1,2,4]triazolo[4,3-a]quinolines and 1,3,4-oxadiazole rings
gan: Aksenov, A. V., et al.
Cyhoeddwyd: (2021)

Rational design of an efficient one-pot synthesis of 6H-pyrrolo[2,3,4- gh] perimidines in polyphosphoric acid
gan: Aksenov, A. V., et al.
Cyhoeddwyd: (2018)

Electrophilically activated nitroalkanes in synthesis of 3,4-dihydroquinozalines
gan: Aksenov, A. V., et al.
Cyhoeddwyd: (2021)

Direct C-H functionalization of arenes in reactions with nitroalkanes and nitroalkenes in polyphosphoric acids
gan: Aksenov, A. V., et al.
Cyhoeddwyd: (2019)

Nitroalkanes as electrophiles: synthesis of triazole-fused heterocycles with neuroblastoma differentiation activity
gan: Aksenov, N. A., et al.
Cyhoeddwyd: (2020)

Dual role of polyphosphoric acid-activated nitroalkanes in oxidative peri -annulations: Efficient synthesis of 1,3,6,8-tetraazapyrenes
gan: Aksenov, A. V., et al.
Cyhoeddwyd: (2018)

One-pot synthesis of 4-methyl-2-alkyl quinazoline-N-oxides by cascade acetamidation–acylation of simple electron-rich arenes with primary nitroalkanes
gan: Grishin, I. Y., et al.
Cyhoeddwyd: (2025)

Electrophilically activated nitroalkanes in reaction with aliphatic diamines en route to imidazolines
gan: Aksenov, A. V., et al.
Cyhoeddwyd: (2019)

Synthesis of 3,4-dihydroisoquinolines using nitroalkanes in polyphosphoric acid
gan: Aksenov, N. A., et al.
Cyhoeddwyd: (2019)

Electrophilic iodonium-ion mediated spirocyclization of 4-(5-(arylethynyl)pyrimidin-4-yl)phenols enroute to spiro[cyclohexa[2,5]diene-1,7′-cyclopenta[d]pyrimidin]-4-one core
gan: Arutiunov, N. A., et al.
Cyhoeddwyd: (2025)

Benzimidazoles and benzoxazoles via the nucleophilic addition of anilines to nitroalkanes
gan: Aksenov, A. V., et al.
Cyhoeddwyd: (2018)

Does electrophilic activation of nitroalkanes in polyphosphoric acid involve formation of nitrile oxides?
gan: Aksenov, A. V., et al.
Cyhoeddwyd: (2021)

One-pot synthesis of benzoxazoles via the metal-free ortho-C-H functionalization of phenols with nitroalkanes
gan: Aksenov, N. A., et al.
Cyhoeddwyd: (2018)

Nitroalkenes as surrogates for cyanomethylium species in a one-pot synthesis of non-symmetric diarylacetonitriles
gan: Aksenov, A. V., et al.
Cyhoeddwyd: (2018)

γ-Hydroxy-γ-butyrolactams as 1,2-bis-electrophiles in a Brønsted/Lewis acid-free synthesis of condensed nitrogen heterocycles
gan: Aksenov, N. A., et al.
Cyhoeddwyd: (2024)

Synthetic studies towards benzofuro[2,3-b]quinoline and 6H-indolo[2,3-b]quinoline cores: Total synthesis of norneocryptolepine and neocryptolepine
gan: Aksenov, D. A., et al.
Cyhoeddwyd: (2021)

A sequence of acylamination and acylation reactions in polyphosphoric acid – a novel approach to the Friedländer synthesis of 2-arylquinolines
gan: Grishin, I. Y., et al.
Cyhoeddwyd: (2023)

One-Pot Synthesis of (E)-2-(3-Oxoindolin-2-Ylidene)-2-Arylacetonitriles
gan: Aksenov, N. A., et al.
Cyhoeddwyd: (2022)

Direct reductive coupling of indoles to nitrostyrenes en route to (indol-3-yl)acetamides
gan: Aksenov, A. V., et al.
Cyhoeddwyd: (2018)

Improved method for preparation of 3-(1H-Indol-3-yl)benzofuran-2(3H)-ones
gan: Grishin, I. Y., et al.
Cyhoeddwyd: (2022)

Direct conversion of 3-(2-nitroethyl)-1H-indoles into 2-(1H-indol-2-yl)acetonitriles
gan: Aksenov, A. V., et al.
Cyhoeddwyd: (2021)

Electrophilically activated nitroalkanes in the synthesis of 6,7-dihydro-1H-cyclopenta[g]perimidines
gan: Aksenov, A. V., et al.
Cyhoeddwyd: (2018)

Unexpected cyclization of 2-(2-aminophenyl)indoles with nitroalkenes to furnish indolo[3,2-: C] quinolines
gan: Aksenov, A. V., et al.
Cyhoeddwyd: (2018)

Direct metal-free synthesis of diarylamines from 2-nitropropane via the twofold C-H functionalization of arenes
gan: Aksenov, A. V., et al.
Cyhoeddwyd: (2019)

THE SEMIOTICS OF INVARIANTS OF THE “WATER” ARCHETYPE (RIVERS, SEAS) IN THE TEXT OF MIKHAIL LERMONTOV’S A HERO OF OUR TIME
gan: Strashkova, O. K., et al.
Cyhoeddwyd: (2025)

Detection of Anomalous Activity in Wireless Communication Channels
gan: Lapina, M. A., et al.
Cyhoeddwyd: (2024)

Analysis of an Existing Method for Detecting Adversarial Attacks on Deep Neural Networks
gan: Lapina, M. A., et al.
Cyhoeddwyd: (2024)

Metal-free ring expansion of indoles with nitroalkenes: A simple, modular approach to 3-substituted 2-quinolones
gan: Aksenov, A. V., et al.
Cyhoeddwyd: (2019)

Pyrimidines as surrogates for 1,3-dicarbonyl compounds in peri annulation of perimidines en route to 1,3-diazapyrenes
gan: Aksenov, A. V., et al.
Cyhoeddwyd: (2018)

Analytical Review of Classification and Clustering Methods of Cyber Attacks Based on Data Mining and Neural Network Approach
gan: Fedina, A. D., et al.
Cyhoeddwyd: (2024)

Информатика
gan: Макарова Н. В., et al.

A Feature Selection Study on the Bot-IoT Dataset Using Ensemble Classification Techniques
gan: Lapina, M. A., et al.
Cyhoeddwyd: (2024)

One-pot synthesis of substituted quinolines and 3,3′-(arylmethylene)bis(1H-indoles) via a metal-free polyphosphoric acid-mediated acetylene hydrolysis strategy
gan: Arutiunov, N. A., et al.
Cyhoeddwyd: (2025)

Countering Radicalization in the North Caucasus Implementation and Challenges
gan: Popov, M. E., et al.
Cyhoeddwyd: (2024)

Synthesis, electrochemical properties, and antioxidant activity of sterically hindered catechols with 1,3,4-oxadiazole, 1,2,4-triazole, thiazole or pyridine fragments
gan: Demidov, O. P., et al.
Cyhoeddwyd: (2024)

Introduction of tetrazol-1-yl and 5-methyltetrazol-1-yl substituents in the phenyl ring of dibenzo-18-crown-6
gan: Aksenov, N. A., et al.
Cyhoeddwyd: (2018)

Modern trends of organic chemistry in russian universities
gan: Aksenov, A. V., et al.
Cyhoeddwyd: (2018)

Локальные и глобальные компьютерные сети методические указания к выполнению лабораторных работ
gan: Захаров А. А.
Cyhoeddwyd: (2013)