New possibilities of the Mannich reaction in the synthesis of N-, S,N-, and Se,N-heterocycles
The review summarizes the results obtained by our research group over the past 15 years in chemistry of N-, S,N-, and Se,N-heterocycles resulted from aminomethlation of a wide range of acyclic and heterocyclic substrates derived from active methylene amides, thioamides, and selenoamides. A series of...
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ir-20.500.12258-55612020-02-17T12:42:33Z New possibilities of the Mannich reaction in the synthesis of N-, S,N-, and Se,N-heterocycles Dotsenko, V. V. Доценко, В. В. Heterocyclization Cyanoselenoacetamide Aminomethylation Mannich reaction Active methylene chalcogen amides Cyanothioacetamide Selenoamides The review summarizes the results obtained by our research group over the past 15 years in chemistry of N-, S,N-, and Se,N-heterocycles resulted from aminomethlation of a wide range of acyclic and heterocyclic substrates derived from active methylene amides, thioamides, and selenoamides. A series of 1,3,5-thia(selena)diazines, 3,7-diazabicyclo[3.3.1] nonanes, 3,5,7,11-tetraazatricyclo[7.3.1.0(2,7)]tridec-2-enes, 1,3,5,7-tetrazocines, and pyrido[1,2-a][1,3,5]triazines were synthesized. The general regularities of the Mannich reaction in the series of N-, S,N-, and Se,N-containing pyridine substrates were discussed. Biological activities of some synthesized compounds were studied to reveal compounds with antiviral, analeptic, anti-inflammatory, and antipyretic activities 2019-06-07T14:02:02Z 2019-06-07T14:02:02Z 2019 Статья Dotsenko, VV; Frolov, KA; Chigorina, EA; Khrustaleva, AN; Bibik, EY; Krivokolysko, SG. New possibilities of the Mannich reaction in the synthesis of N-, S,N-, and Se,N-heterocycles // RUSSIAN CHEMICAL BULLETIN. - 2019. - Том: 68. - Выпуск: 4. - Стр.: 691-707 http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=38&SID=E1BmcFx8KXF5GsBSl3h&page=1&doc=1 http://hdl.handle.net/20.500.12258/5561 en Russian Chemical Bulletin application/pdf application/pdf SPRINGER |
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topic |
Heterocyclization Cyanoselenoacetamide Aminomethylation Mannich reaction Active methylene chalcogen amides Cyanothioacetamide Selenoamides |
spellingShingle |
Heterocyclization Cyanoselenoacetamide Aminomethylation Mannich reaction Active methylene chalcogen amides Cyanothioacetamide Selenoamides Dotsenko, V. V. Доценко, В. В. New possibilities of the Mannich reaction in the synthesis of N-, S,N-, and Se,N-heterocycles |
description |
The review summarizes the results obtained by our research group over the past 15 years in chemistry of N-, S,N-, and Se,N-heterocycles resulted from aminomethlation of a wide range of acyclic and heterocyclic substrates derived from active methylene amides, thioamides, and selenoamides. A series of 1,3,5-thia(selena)diazines, 3,7-diazabicyclo[3.3.1] nonanes, 3,5,7,11-tetraazatricyclo[7.3.1.0(2,7)]tridec-2-enes, 1,3,5,7-tetrazocines, and pyrido[1,2-a][1,3,5]triazines were synthesized. The general regularities of the Mannich reaction in the series of N-, S,N-, and Se,N-containing pyridine substrates were discussed. Biological activities of some synthesized compounds were studied to reveal compounds with antiviral, analeptic, anti-inflammatory, and antipyretic activities |
format |
Статья |
author |
Dotsenko, V. V. Доценко, В. В. |
author_facet |
Dotsenko, V. V. Доценко, В. В. |
author_sort |
Dotsenko, V. V. |
title |
New possibilities of the Mannich reaction in the synthesis of N-, S,N-, and Se,N-heterocycles |
title_short |
New possibilities of the Mannich reaction in the synthesis of N-, S,N-, and Se,N-heterocycles |
title_full |
New possibilities of the Mannich reaction in the synthesis of N-, S,N-, and Se,N-heterocycles |
title_fullStr |
New possibilities of the Mannich reaction in the synthesis of N-, S,N-, and Se,N-heterocycles |
title_full_unstemmed |
New possibilities of the Mannich reaction in the synthesis of N-, S,N-, and Se,N-heterocycles |
title_sort |
new possibilities of the mannich reaction in the synthesis of n-, s,n-, and se,n-heterocycles |
publisher |
SPRINGER |
publishDate |
2019 |
url |
http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=38&SID=E1BmcFx8KXF5GsBSl3h&page=1&doc=1 https://dspace.ncfu.ru/handle/20.500.12258/5561 |
work_keys_str_mv |
AT dotsenkovv newpossibilitiesofthemannichreactioninthesynthesisofnsnandsenheterocycles AT docenkovv newpossibilitiesofthemannichreactioninthesynthesisofnsnandsenheterocycles |
_version_ |
1760602016765181952 |