Synthesis of 3,4-dihydroisoquinolines using nitroalkanes in polyphosphoric acid

Synthesis of 3,4-dihydroisoquinolines using nitroalkanes in polyphosphoric acid

A new method for the synthesis of 6,7-dimethoxy-3,4-dihydroisoquinoline based on the reaction of 2-(3,4-dimethoxyphenyl)ethan-1-amine (homoveratrylamine) with aliphatic nitro compounds in polyphosphoric acid (PPA) was developed

Сохранить в:

Библиографические подробности
Главные авторы:	Aksenov, N. A., Аксенов, Н. А., Malyuga, V. V., Малюга, В. В., Aksenov, D. A., Аксенов, Д. А., Aksenov, A. V., Аксенов, А. В.
Формат:	Статья
Язык:	English
Опубликовано:	SPRINGER 2019
Темы:	6,7-dimethoxy-3,4-dihydroisoquinoline Alkaloids Nitro compounds Phenylethylamines Polyphosphoric acids
Online-ссылка:	https://dspace.ncfu.ru/handle/20.500.12258/5575
Метки:	Добавить метку Нет меток, Требуется 1-ая метка записи!

Схожие документы

A sequence of acylamination and acylation reactions in polyphosphoric acid – a novel approach to the Friedländer synthesis of 2-arylquinolines
Автор: Grishin, I. Y., и др.
Опубликовано: (2023)

Direct C-H functionalization of arenes in reactions with nitroalkanes and nitroalkenes in polyphosphoric acids
Автор: Aksenov, A. V., и др.
Опубликовано: (2019)

Dual role of polyphosphoric acid-activated nitroalkanes in oxidative peri -annulations: Efficient synthesis of 1,3,6,8-tetraazapyrenes
Автор: Aksenov, A. V., и др.
Опубликовано: (2018)

A novel multi-component approach to the synthesis of pyrrolo[2,1-a] isoquinoline derivatives
Автор: Aksenov, A. V., и др.
Опубликовано: (2018)

Synthesis of 11H-indolo[3,2-c]quinolines by SnCl4-catalyzed cyclization of indole-3-carbaldehyde oximes
Автор: Aksenov, N. A., и др.
Опубликовано: (2020)

Does electrophilic activation of nitroalkanes in polyphosphoric acid involve formation of nitrile oxides?
Автор: Aksenov, A. V., и др.
Опубликовано: (2021)

Rational design of an efficient one-pot synthesis of 6H-pyrrolo[2,3,4- gh] perimidines in polyphosphoric acid
Автор: Aksenov, A. V., и др.
Опубликовано: (2018)

Reactions of 3,4-dihydroisoquinolines and dihydrothieno[3,2-c]pyridines with benzyne
Автор: Aksenov, A. V., и др.
Опубликовано: (2018)

Nitrovinylindoles as Heterotrienes: Electrocyclic Cyclization En Route to β-Carbolines: Total Synthesis of Alkaloids Norharmane, Harmane, and Eudistomin N
Автор: Aksenov, N. A., и др.
Опубликовано: (2022)

Synthetic studies towards benzofuro[2,3-b]quinoline and 6H-indolo[2,3-b]quinoline cores: Total synthesis of norneocryptolepine and neocryptolepine
Автор: Aksenov, D. A., и др.
Опубликовано: (2021)

SNH Arylamination of 5(6,7,8)-nitroquinoline N-oxides
Автор: Pobedinskaya, D. Y., и др.
Опубликовано: (2023)

Electrophilically activated nitroalkanes in synthesis of 3,4-dihydroquinozalines
Автор: Aksenov, A. V., и др.
Опубликовано: (2021)

Electrophilic activation of nitroalkanes in efficient synthesis of 1,3,4-oxadiazoles
Автор: Aksenov, A. V., и др.
Опубликовано: (2019)

One-pot synthesis of 4-methyl-2-alkyl quinazoline-N-oxides by cascade acetamidation–acylation of simple electron-rich arenes with primary nitroalkanes
Автор: Grishin, I. Y., и др.
Опубликовано: (2025)

A Diastereoselective Assembly of Tetralone Derivatives via a Tandem Michael Reaction and ipso-Substitution of the Nitro Group
Автор: Aksenov, N. A., и др.
Опубликовано: (2023)

6-(Pyrazol-1-yl)pyrazolo[3,4-b]pyridines: Synthesis, Structure, and Wheat Growth Regulating Activity
Автор: Dotsenko, V. V., и др.
Опубликовано: (2024)

One-pot synthesis of substituted quinolines and 3,3′-(arylmethylene)bis(1H-indoles) via a metal-free polyphosphoric acid-mediated acetylene hydrolysis strategy
Автор: Arutiunov, N. A., и др.
Опубликовано: (2025)

New 6'-Amino-5'-cyano-2-oxo-1,2-dihydro-1'H-spiro[indole-3,4'-pyridine]-3'-carboxamides: Synthesis, Reactions, Molecular Docking Studies and Biological Activity
Автор: Dotsenko, V. V., и др.
Опубликовано: (2023)

Direct reductive coupling of indoles to nitrostyrenes en route to (indol-3-yl)acetamides
Автор: Aksenov, A. V., и др.
Опубликовано: (2018)

Alkyl 4-Aryl-6-amino-7- phenyl-3-(phenylimino)-4,7-dihydro- 3H-[1,2]dithiolo[3,4-b]pyridine-5-carboxylates: Synthesis and Agrochemical Studies
Автор: Dotsenko, V. V., и др.
Опубликовано: (2023)

Synthesis of 2,4-Disubstituted Quinolines by the Reaction of Propargylic Alcohols with Anilines in a Polyphosphoric Acid Medium
Автор: Aksenov, A. V., и др.
Опубликовано: (2025)

Unexpected cyclization of 2-(2-aminophenyl)indoles with nitroalkenes to furnish indolo[3,2-: C] quinolines
Автор: Aksenov, A. V., и др.
Опубликовано: (2018)

Electrophilically activated nitroalkanes in the synthesis of substituted 1,3,4-oxadiazoles from amino acid derivatives
Автор: Aksenov, A. V., и др.
Опубликовано: (2022)

Direct metal-free synthesis of diarylamines from 2-nitropropane via the twofold C-H functionalization of arenes
Автор: Aksenov, A. V., и др.
Опубликовано: (2019)

Regioselective Nitration of (2E)-3-Aryl-2-(4-arylthiazol-2-yl)acrylonitriles
Автор: Dotsenko, V. V., и др.
Опубликовано: (2024)

Pyrimidines as surrogates for 1,3-dicarbonyl compounds in peri annulation of perimidines en route to 1,3-diazapyrenes
Автор: Aksenov, A. V., и др.
Опубликовано: (2018)

Metal-free ring expansion of indoles with nitroalkenes: A simple, modular approach to 3-substituted 2-quinolones
Автор: Aksenov, A. V., и др.
Опубликовано: (2019)

Pseudo Four-Component Cyclocondensation of N-Alkylpiperidin-4-ones, Malononitrile, and Acetone
Автор: Dotsenko, V. V., и др.
Опубликовано: (2025)

Electrophilically activated nitroalkanes in reaction with aliphatic diamines en route to imidazolines
Автор: Aksenov, A. V., и др.
Опубликовано: (2019)

The Reactions of N,N′-Diphenyldithiomalondiamide with Arylmethylidene Meldrum’s Acids
Автор: Dotsenko, V. V., и др.
Опубликовано: (2023)

Nitroalkanes as electrophiles: synthesis of triazole-fused heterocycles with neuroblastoma differentiation activity
Автор: Aksenov, N. A., и др.
Опубликовано: (2020)

Photophysical properties of 2’-hydroxychalcones of 2-cinnamoyl-4-nitro-1-naphthol series
Автор: Batalin, S. D., и др.
Опубликовано: (2024)

Benzimidazoles and benzoxazoles via the nucleophilic addition of anilines to nitroalkanes
Автор: Aksenov, A. V., и др.
Опубликовано: (2018)

Synthesis of new functionalized 3,7-diazabicyclo[3.3.1]nonanes by aminomethylation of the Guareschi imides
Автор: Dotsenko, V. V., и др.
Опубликовано: (2018)

An efficient approach to 2-CF3-indoles based on ortho-nitrobenzaldehydes
Автор: Abaev, V. T., и др.
Опубликовано: (2021)

Methylation of 2-Aryl-2-(3-indolyl)acetohydroxamic acids and evaluation of cytotoxic activity of the products
Автор: Aksenov, D. A., и др.
Опубликовано: (2022)

γ-Hydroxy-γ-butyrolactams as 1,2-bis-electrophiles in a Brønsted/Lewis acid-free synthesis of condensed nitrogen heterocycles
Автор: Aksenov, N. A., и др.
Опубликовано: (2024)

One-pot synthesis of benzoxazoles via the metal-free ortho-C-H functionalization of phenols with nitroalkanes
Автор: Aksenov, N. A., и др.
Опубликовано: (2018)

1,6-Diamino-2-oxopyridine-3,5-dicarbonitrile Derivatives in the Mannich Reaction
Автор: Dotsenko, V. V., и др.
Опубликовано: (2021)

Electrophilically activated nitroalkanes in double annulation of [1,2,4]triazolo[4,3-a]quinolines and 1,3,4-oxadiazole rings
Автор: Aksenov, A. V., и др.
Опубликовано: (2021)