Probing chemical space of tick-borne encephalitis virus reproduction inhibitors with organoselenium compounds
Tick-borne encephalitis virus (TBEV), a member of the genus Flavivirus, is the leading cause of arboviral neuroinfections in Europe. Only a few classes of the nucleoside and non-nucleoside inhibitors were investigated against TBEV reproduction. Paving the way to previously unexplored areas of anti-T...
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| स्वरूप: | Статья |
| भाषा: | English |
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Wiley-VCH Verlag
2018
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| ऑनलाइन पहुंच: | https://www.scopus.com/record/display.uri?eid=2-s2.0-85046075473&origin=resultslist&sort=plf-f&src=s&nlo=1&nlr=20&nls=afprfnm-t&affilName=nort*+caucas*+fed*+univ*&sid=762e6d30544023d6a322a94577ba172b&sot=afnl&sdt=afsp&sl=53&s=%28AF-ID%28%22North+Caucasus+Federal+University%22+60070541%29%29&relpos=3&citeCnt=0&searchTerm= https://dspace.ncfu.ru:443/handle/20.500.12258/609 |
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ir-20.500.12258-6092020-07-10T08:03:05Z Probing chemical space of tick-borne encephalitis virus reproduction inhibitors with organoselenium compounds Dotsenko, V. V. Доценко, В. В. Antivirals Flavivirus Organoselenium compounds Tick-borne encephalitis virus Tick-borne encephalitis virus (TBEV), a member of the genus Flavivirus, is the leading cause of arboviral neuroinfections in Europe. Only a few classes of the nucleoside and non-nucleoside inhibitors were investigated against TBEV reproduction. Paving the way to previously unexplored areas of anti-TBEV chemical space, we assessed the inhibition of TBEV reproduction in the plaque reduction assay by various compounds derived from cyanothioacetamide and cyanoselenoacetamide. Compounds from seven classes, including 4-(alkylthio)-2-aryl-3-azaspiro[5.5]undec-4-ene-1,1,5-tricarbonitriles, 3-arylamino-2-(selenazol-2-yl)acrylonitriles, ethyl 6-(alkylseleno)-5-cyano-2-oxo-1,2-dihydropyridine-3-carboxylates, 6-(alkylseleno)-2-oxo-1,4,5,6-tetrahydropyridine-3-carbonitriles, 2-(alkylseleno)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitriles, 8-selenoxo-3,5,7,11-tetraazatricyclo[7.3.1.02,7]tridec-2-ene-1,9-dicarbonitriles, and selenolo[2,3-b]quinolines, inhibited TBEV reproduction with EC50 values in the micromolar range while showing moderate cytotoxicity and no inhibition of enterovirus reproduction. Thus, new scaffolds with promising anti-TBEV activity were found 2018-06-18T12:23:01Z 2018-06-18T12:23:01Z 2018 Статья Orlov, A.A., Eletskaya, A.A., Frolov, K.A., Golinets, A.D., Palyulin, V.A., Krivokolysko, S.G., Kozlovskaya, L.I., Dotsenko, V.V., Osolodkin, D.I. Probing chemical space of tick-borne encephalitis virus reproduction inhibitors with organoselenium compounds // Archiv der Pharmazie. - 2018. - Volume 351. - Issue 6. - статья №1700353. https://www.scopus.com/record/display.uri?eid=2-s2.0-85046075473&origin=resultslist&sort=plf-f&src=s&nlo=1&nlr=20&nls=afprfnm-t&affilName=nort*+caucas*+fed*+univ*&sid=762e6d30544023d6a322a94577ba172b&sot=afnl&sdt=afsp&sl=53&s=%28AF-ID%28%22North+Caucasus+Federal+University%22+60070541%29%29&relpos=3&citeCnt=0&searchTerm= https://dspace.ncfu.ru:443/handle/20.500.12258/609 en Archiv der Pharmazie application/pdf application/pdf Wiley-VCH Verlag |
| institution |
СКФУ |
| collection |
Репозиторий |
| language |
English |
| topic |
Antivirals Flavivirus Organoselenium compounds Tick-borne encephalitis virus |
| spellingShingle |
Antivirals Flavivirus Organoselenium compounds Tick-borne encephalitis virus Dotsenko, V. V. Доценко, В. В. Probing chemical space of tick-borne encephalitis virus reproduction inhibitors with organoselenium compounds |
| description |
Tick-borne encephalitis virus (TBEV), a member of the genus Flavivirus, is the leading cause of arboviral neuroinfections in Europe. Only a few classes of the nucleoside and non-nucleoside inhibitors were investigated against TBEV reproduction. Paving the way to previously unexplored areas of anti-TBEV chemical space, we assessed the inhibition of TBEV reproduction in the plaque reduction assay by various compounds derived from cyanothioacetamide and cyanoselenoacetamide. Compounds from seven classes, including 4-(alkylthio)-2-aryl-3-azaspiro[5.5]undec-4-ene-1,1,5-tricarbonitriles, 3-arylamino-2-(selenazol-2-yl)acrylonitriles, ethyl 6-(alkylseleno)-5-cyano-2-oxo-1,2-dihydropyridine-3-carboxylates, 6-(alkylseleno)-2-oxo-1,4,5,6-tetrahydropyridine-3-carbonitriles, 2-(alkylseleno)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitriles, 8-selenoxo-3,5,7,11-tetraazatricyclo[7.3.1.02,7]tridec-2-ene-1,9-dicarbonitriles, and selenolo[2,3-b]quinolines, inhibited TBEV reproduction with EC50 values in the micromolar range while showing moderate cytotoxicity and no inhibition of enterovirus reproduction. Thus, new scaffolds with promising anti-TBEV activity were found |
| format |
Статья |
| author |
Dotsenko, V. V. Доценко, В. В. |
| author_facet |
Dotsenko, V. V. Доценко, В. В. |
| author_sort |
Dotsenko, V. V. |
| title |
Probing chemical space of tick-borne encephalitis virus reproduction inhibitors with organoselenium compounds |
| title_short |
Probing chemical space of tick-borne encephalitis virus reproduction inhibitors with organoselenium compounds |
| title_full |
Probing chemical space of tick-borne encephalitis virus reproduction inhibitors with organoselenium compounds |
| title_fullStr |
Probing chemical space of tick-borne encephalitis virus reproduction inhibitors with organoselenium compounds |
| title_full_unstemmed |
Probing chemical space of tick-borne encephalitis virus reproduction inhibitors with organoselenium compounds |
| title_sort |
probing chemical space of tick-borne encephalitis virus reproduction inhibitors with organoselenium compounds |
| publisher |
Wiley-VCH Verlag |
| publishDate |
2018 |
| url |
https://www.scopus.com/record/display.uri?eid=2-s2.0-85046075473&origin=resultslist&sort=plf-f&src=s&nlo=1&nlr=20&nls=afprfnm-t&affilName=nort*+caucas*+fed*+univ*&sid=762e6d30544023d6a322a94577ba172b&sot=afnl&sdt=afsp&sl=53&s=%28AF-ID%28%22North+Caucasus+Federal+University%22+60070541%29%29&relpos=3&citeCnt=0&searchTerm= https://dspace.ncfu.ru:443/handle/20.500.12258/609 |
| work_keys_str_mv |
AT dotsenkovv probingchemicalspaceoftickborneencephalitisvirusreproductioninhibitorswithorganoseleniumcompounds AT docenkovv probingchemicalspaceoftickborneencephalitisvirusreproductioninhibitorswithorganoseleniumcompounds |
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1760600773367955456 |