Michael addition to 3-(2-nitrovinyl)indoles – route toward aliphatic nitro compounds with heterocyclic substituents

Synthetic approach toward indole derivatives bearing 2-nitroethyl group and polar azole moiety has been developed. This method involves conjugate addition of 1,3-dicarbonyl compounds to 3-(2-nitrovinyl)-1H-indoles followed by cyclocondensation with hydrazine or hydroxylamine to furnish pyrazole or i...

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Главные авторы:	Aksenov, N. A., Аксенов, Н. А., Skomorokhov, A. A., Скоморохов, А. А., Aksenov, A. V., Аксенов, А. В., Rubin, M. A., Рубин, М. А.
Формат:	Статья
Язык:	English
Опубликовано:	Springer New York LLC 2019
Темы:	Indole Isoxazole Michael addition Microwave-assisted synthesis Nitroalkenes Pyrazole
Online-ссылка:	https://dspace.ncfu.ru/handle/20.500.12258/7502
Метки:	Добавить метку Нет меток, Требуется 1-ая метка записи!

id	ir-20.500.12258-7502
record_format	dspace
spelling	ir-20.500.12258-75022025-02-13T10:15:47Z Michael addition to 3-(2-nitrovinyl)indoles – route toward aliphatic nitro compounds with heterocyclic substituents Aksenov, N. A. Аксенов, Н. А. Skomorokhov, A. A. Скоморохов, А. А. Aksenov, A. V. Аксенов, А. В. Rubin, M. A. Рубин, М. А. Indole Isoxazole Michael addition Microwave-assisted synthesis Nitroalkenes Pyrazole Synthetic approach toward indole derivatives bearing 2-nitroethyl group and polar azole moiety has been developed. This method involves conjugate addition of 1,3-dicarbonyl compounds to 3-(2-nitrovinyl)-1H-indoles followed by cyclocondensation with hydrazine or hydroxylamine to furnish pyrazole or isoxazole ring. Application of microwave activation allows to obtain the target indole derivatives in short time and avoid protection of indole nitrogen atom 2019-09-25T12:22:39Z 2019-09-25T12:22:39Z 2019 Статья Aksenov, N.A., Skomorokhov, A.A., Aksenov, A.V., Voskressensky, L.G., Rubin, M.A. Michael addition to 3-(2-nitrovinyl)indoles – route toward aliphatic nitro compounds with heterocyclic substituents // Chemistry of Heterocyclic Compounds. - 2019. - Volume 55. - Issue 6. - Pages 541-546 http://hdl.handle.net/20.500.12258/7502 en Chemistry of Heterocyclic Compounds application/pdf application/pdf Springer New York LLC
institution	СКФУ
collection	Репозиторий
language	English
topic	Indole Isoxazole Michael addition Microwave-assisted synthesis Nitroalkenes Pyrazole
spellingShingle	Indole Isoxazole Michael addition Microwave-assisted synthesis Nitroalkenes Pyrazole Aksenov, N. A. Аксенов, Н. А. Skomorokhov, A. A. Скоморохов, А. А. Aksenov, A. V. Аксенов, А. В. Rubin, M. A. Рубин, М. А. Michael addition to 3-(2-nitrovinyl)indoles – route toward aliphatic nitro compounds with heterocyclic substituents
description	Synthetic approach toward indole derivatives bearing 2-nitroethyl group and polar azole moiety has been developed. This method involves conjugate addition of 1,3-dicarbonyl compounds to 3-(2-nitrovinyl)-1H-indoles followed by cyclocondensation with hydrazine or hydroxylamine to furnish pyrazole or isoxazole ring. Application of microwave activation allows to obtain the target indole derivatives in short time and avoid protection of indole nitrogen atom
format	Статья
author	Aksenov, N. A. Аксенов, Н. А. Skomorokhov, A. A. Скоморохов, А. А. Aksenov, A. V. Аксенов, А. В. Rubin, M. A. Рубин, М. А.
author_facet	Aksenov, N. A. Аксенов, Н. А. Skomorokhov, A. A. Скоморохов, А. А. Aksenov, A. V. Аксенов, А. В. Rubin, M. A. Рубин, М. А.
author_sort	Aksenov, N. A.
title	Michael addition to 3-(2-nitrovinyl)indoles – route toward aliphatic nitro compounds with heterocyclic substituents
title_short	Michael addition to 3-(2-nitrovinyl)indoles – route toward aliphatic nitro compounds with heterocyclic substituents
title_full	Michael addition to 3-(2-nitrovinyl)indoles – route toward aliphatic nitro compounds with heterocyclic substituents
title_fullStr	Michael addition to 3-(2-nitrovinyl)indoles – route toward aliphatic nitro compounds with heterocyclic substituents
title_full_unstemmed	Michael addition to 3-(2-nitrovinyl)indoles – route toward aliphatic nitro compounds with heterocyclic substituents
title_sort	michael addition to 3-(2-nitrovinyl)indoles – route toward aliphatic nitro compounds with heterocyclic substituents
publisher	Springer New York LLC
publishDate	2019
url	https://dspace.ncfu.ru/handle/20.500.12258/7502
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Michael addition to 3-(2-nitrovinyl)indoles – route toward aliphatic nitro compounds with heterocyclic substituents

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