Synthesis and properties of 4,6-Dimethyl-5-pentyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile and 3-Amino-4,6-dimethyl-5-pentylthieno[2,3-b]pyridines
The reaction of 3-pentylpentane-2,4-dione with cyanothioacetamide afforded 4,6-dimethyl-5-pentyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile. Alkylation of the latter led to the formation of 2-alkylsulfanyl-4,6-dimethyl-5-pentylpyridine-3-carbonitriles or 3-amino-4,6-dimethyl-5-pentylthieno[2,3-b]py...
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| Autores principales: | , , , , , |
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| Formato: | Статья |
| Lenguaje: | English |
| Publicado: |
Pleiades Publishing
2019
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| Materias: | |
| Acceso en línea: | https://www.scopus.com/record/display.uri?eid=2-s2.0-85073000711&origin=resultslist&sort=plf-f&src=s&st1=Synthesis+and+Properties+of+4%2c6-Dimethyl-5-pentyl-2-thioxo-1%2c2-dihydropyridine-3-carbonitrile+and+3-Amino-4%2c6-dimethyl-5-pentylthieno&st2=&sid=a07413b3d3e0280d7630b8ca0d7daa23&sot=b&sdt=b&sl=148&s=TITLE-ABS-KEY%28Synthesis+and+Properties+of+4%2c6-Dimethyl-5-pentyl-2-thioxo-1%2c2-dihydropyridine-3-carbonitrile+and+3-Amino-4%2c6-dimethyl-5-pentylthieno%29&relpos=0&citeCnt=0&searchTerm= https://dspace.ncfu.ru/handle/20.500.12258/8004 |
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| Sumario: | The reaction of 3-pentylpentane-2,4-dione with cyanothioacetamide afforded 4,6-dimethyl-5-pentyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile. Alkylation of the latter led to the formation of 2-alkylsulfanyl-4,6-dimethyl-5-pentylpyridine-3-carbonitriles or 3-amino-4,6-dimethyl-5-pentylthieno[2,3-b]pyridines, depending on the alkylating agent and reaction conditions. The structures of the key compounds were proved by 2D NMR spectroscopy and X-ray analysis. Biological activity of the synthesized compounds was evaluated in silico. Some compounds were experimentally found to stimulate growth of sunflower seedlings |
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