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Synthesis and properties of 4,6-Dimethyl-5-pentyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile and 3-Amino-4,6-dimethyl-5-pentylthieno[2,3-b]pyridines

Synthesis and properties of 4,6-Dimethyl-5-pentyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile and 3-Amino-4,6-dimethyl-5-pentylthieno[2,3-b]pyridines

The reaction of 3-pentylpentane-2,4-dione with cyanothioacetamide afforded 4,6-dimethyl-5-pentyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile. Alkylation of the latter led to the formation of 2-alkylsulfanyl-4,6-dimethyl-5-pentylpyridine-3-carbonitriles or 3-amino-4,6-dimethyl-5-pentylthieno[2,3-b]py...

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Главные авторы: Dotsenko, V. V., Доценко, В. В., Aksenov, N. A., Аксенов, Н. А., Aksenova, I. V., Аксенова, И. В.
Formato: Статья
Idioma:English
Publicado: Pleiades Publishing 2019
Темы:
1,3,2λ5-diazaphosphinines
Cyanothioacetamide
In silico biological activity
Lipophilicity
Thieno[2,3-b]pyridines
Thorpe-Ziegler cyclization
Acceso en liña:https://www.scopus.com/record/display.uri?eid=2-s2.0-85073000711&origin=resultslist&sort=plf-f&src=s&st1=Synthesis+and+Properties+of+4%2c6-Dimethyl-5-pentyl-2-thioxo-1%2c2-dihydropyridine-3-carbonitrile+and+3-Amino-4%2c6-dimethyl-5-pentylthieno&st2=&sid=a07413b3d3e0280d7630b8ca0d7daa23&sot=b&sdt=b&sl=148&s=TITLE-ABS-KEY%28Synthesis+and+Properties+of+4%2c6-Dimethyl-5-pentyl-2-thioxo-1%2c2-dihydropyridine-3-carbonitrile+and+3-Amino-4%2c6-dimethyl-5-pentylthieno%29&relpos=0&citeCnt=0&searchTerm=
https://dspace.ncfu.ru/handle/20.500.12258/8004
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https://www.scopus.com/record/display.uri?eid=2-s2.0-85073000711&origin=resultslist&sort=plf-f&src=s&st1=Synthesis+and+Properties+of+4%2c6-Dimethyl-5-pentyl-2-thioxo-1%2c2-dihydropyridine-3-carbonitrile+and+3-Amino-4%2c6-dimethyl-5-pentylthieno&st2=&sid=a07413b3d3e0280d7630b8ca0d7daa23&sot=b&sdt=b&sl=148&s=TITLE-ABS-KEY%28Synthesis+and+Properties+of+4%2c6-Dimethyl-5-pentyl-2-thioxo-1%2c2-dihydropyridine-3-carbonitrile+and+3-Amino-4%2c6-dimethyl-5-pentylthieno%29&relpos=0&citeCnt=0&searchTerm=
https://dspace.ncfu.ru/handle/20.500.12258/8004

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