Synthesis and properties of new fluorine-containing thieno[2,3-b]pyridine derivatives

Cyanothioacetamide reacted with 1,1,5,5-tetrafluoroacetylacetone to give 4,6-bis(difluoromethyl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile, and alkylation of the latter with α-chloroacetamides afforded 3-amino-4,6-bis(difluoromethyl)thieno[2,3-b]pyridine-2-carboxamides. The structure of the key co...

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Главные авторы:	Dotsenko, V. V., Доценко, В. В., Aksenov, N. A., Аксенов, Н. А., Aksenova, I. V., Аксенова, И. В.
Формат:	Статья
Язык:	English
Опубликовано:	Pleiades Publishing 2019
Темы:	Cyanothioacetamide Guareschi-Thorpe reaction In silico biological activity Organic fluorides Thieno[2,3-b]pyridines Thorpe-Ziegler cyclization
Online-ссылка:	https://dspace.ncfu.ru/handle/20.500.12258/8307
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spelling	ir-20.500.12258-83072025-02-13T09:09:37Z Synthesis and properties of new fluorine-containing thieno[2,3-b]pyridine derivatives Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В. Cyanothioacetamide Guareschi-Thorpe reaction In silico biological activity Organic fluorides Thieno[2,3-b]pyridines Thorpe-Ziegler cyclization Cyanothioacetamide reacted with 1,1,5,5-tetrafluoroacetylacetone to give 4,6-bis(difluoromethyl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile, and alkylation of the latter with α-chloroacetamides afforded 3-amino-4,6-bis(difluoromethyl)thieno[2,3-b]pyridine-2-carboxamides. The structure of the key compounds was proved using two-dimensional NMR techniques. In silico analysis of potential biological activity and bioavailability of the synthesized compounds was performed 2019-11-13T10:05:28Z 2019-11-13T10:05:28Z 2019 Статья Buryi, D.S., Dotsenko, V.V., Aksenov, N.A., Aksenova, I.V. Synthesis and Properties of New Fluorine-Containing Thieno[2,3-b]pyridine Derivatives // Russian Journal of General Chemistry. - 2019. - Volume 89. - Issue 9. - Pages 1744-1751 http://hdl.handle.net/20.500.12258/8307 en Russian Journal of General Chemistry application/pdf application/pdf Pleiades Publishing
institution	СКФУ
collection	Репозиторий
language	English
topic	Cyanothioacetamide Guareschi-Thorpe reaction In silico biological activity Organic fluorides Thieno[2,3-b]pyridines Thorpe-Ziegler cyclization
spellingShingle	Cyanothioacetamide Guareschi-Thorpe reaction In silico biological activity Organic fluorides Thieno[2,3-b]pyridines Thorpe-Ziegler cyclization Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В. Synthesis and properties of new fluorine-containing thieno[2,3-b]pyridine derivatives
description	Cyanothioacetamide reacted with 1,1,5,5-tetrafluoroacetylacetone to give 4,6-bis(difluoromethyl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile, and alkylation of the latter with α-chloroacetamides afforded 3-amino-4,6-bis(difluoromethyl)thieno[2,3-b]pyridine-2-carboxamides. The structure of the key compounds was proved using two-dimensional NMR techniques. In silico analysis of potential biological activity and bioavailability of the synthesized compounds was performed
format	Статья
author	Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В.
author_facet	Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В.
author_sort	Dotsenko, V. V.
title	Synthesis and properties of new fluorine-containing thieno[2,3-b]pyridine derivatives
title_short	Synthesis and properties of new fluorine-containing thieno[2,3-b]pyridine derivatives
title_full	Synthesis and properties of new fluorine-containing thieno[2,3-b]pyridine derivatives
title_fullStr	Synthesis and properties of new fluorine-containing thieno[2,3-b]pyridine derivatives
title_full_unstemmed	Synthesis and properties of new fluorine-containing thieno[2,3-b]pyridine derivatives
title_sort	synthesis and properties of new fluorine-containing thieno[2,3-b]pyridine derivatives
publisher	Pleiades Publishing
publishDate	2019
url	https://dspace.ncfu.ru/handle/20.500.12258/8307
work_keys_str_mv	AT dotsenkovv synthesisandpropertiesofnewfluorinecontainingthieno23bpyridinederivatives AT docenkovv synthesisandpropertiesofnewfluorinecontainingthieno23bpyridinederivatives AT aksenovna synthesisandpropertiesofnewfluorinecontainingthieno23bpyridinederivatives AT aksenovna synthesisandpropertiesofnewfluorinecontainingthieno23bpyridinederivatives AT aksenovaiv synthesisandpropertiesofnewfluorinecontainingthieno23bpyridinederivatives AT aksenovaiv synthesisandpropertiesofnewfluorinecontainingthieno23bpyridinederivatives
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Synthesis and properties of new fluorine-containing thieno[2,3-b]pyridine derivatives

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