Structural and Functional Arrangement of the Vascular Bed and Bone Morphology in Patients with Connective Tissue Dysplasia Syndrome
The article offers a view at the features of the histostructure and angioarchitectonics of the jaws alveolar process bone tissue in individuals suffering from the syndrome of undifferentiated connective tissue dysplasia (UCTD). The arrangement of the vascular bed as well as that of the qualitative a...
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| Автори: | , , , |
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| Формат: | Статья |
| Мова: | English |
| Опубліковано: |
University of Dicle
2024
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| Предмети: | |
| Онлайн доступ: | https://dspace.ncfu.ru/handle/123456789/29146 |
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| Резюме: | The article offers a view at the features of the histostructure and angioarchitectonics of the jaws alveolar process bone tissue in individuals suffering from the syndrome of undifferentiated connective tissue dysplasia (UCTD). The arrangement of the vascular bed as well as that of the qualitative and quantitative indicators of the alveolar bone was assessed relying on sectional material using histological, morphometric studies and the atomic force microscopy method based on specifically developed criteria. The participants were divided into two groups, namely, Group 1 (n=17) with no background pathology; Group 2 (n=22) − patients UCTD syndrome featuring at least 6 locomotor and locomotor-visceral signs with at least 2-3 organs affected. When examining the histostructure, the preparations were stained with hematoxylin and eosin, picrofuxin (by Van Gieson), whereas the morphometric analysis of the bone tissue and vascular system images was performed using the ImageJ software package; the ultrastructural arrangement was studied employing a scanning probe microscope. A significant deterioration involving the qualitative and quantitative specifics of the histoarchitecture of the alveolar bone in individuals featuring UCTD signs, if compared to the control group, could be observed through a shift in the compact and spongy to spongy matter ratio; degenerative changes in osteocytes; expansion of Haversian osteons; autolytic resorption foci; submicroscopic changes in linear, volumetric and spatial parameters of collagen fibers; reduced number and diameter of blood vessels. Disturbed arrangement of the vascular bed, as well as morphological changes involving the jaw bones in patients with UCTD syndrome point at incomplete “maturation” of the maxillofacial area bone structures; progressing degenerative and sclerotic changes typical of osteoporosis, and a slowdown in the local microcirculation, which is a reflection of the specifics of collagenopathy-related connective tissue metabolism. A decrease in the mineral saturation, and demineralization, lead to lower bone tissue resistance as well as it increases the potential for bone fractures and other consequences of traumatic effects. |
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