Probiotics in colorectal cancer prevention and therapy: mechanisms, benefits, and challenges

Colorectal cancer (CRC) is the third most diagnosed cancer and the second leading cause of morbidity worldwide. In Algeria, it ranks second in mortality-related deaths. Poor lifestyle, characterized by a low-fiber diet, insufficient physical activity, tobacco use, and alcohol consumption, is strongl...

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Главные авторы:	Nagdalian, A. A., Нагдалян, А. А.
Формат:	Статья
Язык:	English
Опубликовано:	Springer Science and Business Media B.V. 2025
Темы:	Colorectal cancer Microbiome Efficacy Inflammation Probiotics Safety
Online-ссылка:	https://dspace.ncfu.ru/handle/123456789/30420
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spelling	ir-123456789-304202025-05-06T13:36:44Z Probiotics in colorectal cancer prevention and therapy: mechanisms, benefits, and challenges Nagdalian, A. A. Нагдалян, А. А. Colorectal cancer Microbiome Efficacy Inflammation Probiotics Safety Colorectal cancer (CRC) is the third most diagnosed cancer and the second leading cause of morbidity worldwide. In Algeria, it ranks second in mortality-related deaths. Poor lifestyle, characterized by a low-fiber diet, insufficient physical activity, tobacco use, and alcohol consumption, is strongly associated with an increased risk of developing this disease. Probiotics have demonstrated anti-inflammatory and antitumor effects in preclinical and clinical studies. The World Health Organization (WHO) and European Food Safety Authority (EFSA) have recognized their safety and effectiveness, classifying them as Generally Recognized as Safe (GRAS) and Qualified Presumption of Safety (QPS), respectively. Probiotics exhibit immunomodulatory effects and maintain the equilibrium of the gut microbiota. However, the evidence for their clinical efficacy is inadequate, and additional research is requisite to establish them as therapeutic agents rather than simply as dietary supplements. Although probiotics are, in most cases, safe, high-risk patients should exercise caution due to the potential risk of infection. This review examines the current knowledge on probiotic strains, their therapeutic potential for colorectal cancer, limitations, and areas where further research is imperative to improve their efficacy. 2025-05-06T13:35:42Z 2025-05-06T13:35:42Z 2025 Статья Morsli D.S., Tbahriti H.F., Rahli F., Mahammi F.Z., Nagdalian A., Hemeg H.A., Imran M., Rauf A., Shariati M.A. Probiotics in colorectal cancer prevention and therapy: mechanisms, benefits, and challenges // Discover Oncology. - 2025. - 16 (1). - art. no. 406. - DOI: 10.1007/s12672-025-01996-4 https://dspace.ncfu.ru/handle/123456789/30420 en Discover Oncology application/pdf application/pdf Springer Science and Business Media B.V.
institution	СКФУ
collection	Репозиторий
language	English
topic	Colorectal cancer Microbiome Efficacy Inflammation Probiotics Safety
spellingShingle	Colorectal cancer Microbiome Efficacy Inflammation Probiotics Safety Nagdalian, A. A. Нагдалян, А. А. Probiotics in colorectal cancer prevention and therapy: mechanisms, benefits, and challenges
description	Colorectal cancer (CRC) is the third most diagnosed cancer and the second leading cause of morbidity worldwide. In Algeria, it ranks second in mortality-related deaths. Poor lifestyle, characterized by a low-fiber diet, insufficient physical activity, tobacco use, and alcohol consumption, is strongly associated with an increased risk of developing this disease. Probiotics have demonstrated anti-inflammatory and antitumor effects in preclinical and clinical studies. The World Health Organization (WHO) and European Food Safety Authority (EFSA) have recognized their safety and effectiveness, classifying them as Generally Recognized as Safe (GRAS) and Qualified Presumption of Safety (QPS), respectively. Probiotics exhibit immunomodulatory effects and maintain the equilibrium of the gut microbiota. However, the evidence for their clinical efficacy is inadequate, and additional research is requisite to establish them as therapeutic agents rather than simply as dietary supplements. Although probiotics are, in most cases, safe, high-risk patients should exercise caution due to the potential risk of infection. This review examines the current knowledge on probiotic strains, their therapeutic potential for colorectal cancer, limitations, and areas where further research is imperative to improve their efficacy.
format	Статья
author	Nagdalian, A. A. Нагдалян, А. А.
author_facet	Nagdalian, A. A. Нагдалян, А. А.
author_sort	Nagdalian, A. A.
title	Probiotics in colorectal cancer prevention and therapy: mechanisms, benefits, and challenges
title_short	Probiotics in colorectal cancer prevention and therapy: mechanisms, benefits, and challenges
title_full	Probiotics in colorectal cancer prevention and therapy: mechanisms, benefits, and challenges
title_fullStr	Probiotics in colorectal cancer prevention and therapy: mechanisms, benefits, and challenges
title_full_unstemmed	Probiotics in colorectal cancer prevention and therapy: mechanisms, benefits, and challenges
title_sort	probiotics in colorectal cancer prevention and therapy: mechanisms, benefits, and challenges
publisher	Springer Science and Business Media B.V.
publishDate	2025
url	https://dspace.ncfu.ru/handle/123456789/30420
work_keys_str_mv	AT nagdalianaa probioticsincolorectalcancerpreventionandtherapymechanismsbenefitsandchallenges AT nagdalânaa probioticsincolorectalcancerpreventionandtherapymechanismsbenefitsandchallenges
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Probiotics in colorectal cancer prevention and therapy: mechanisms, benefits, and challenges

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