Histological studies of organs in experiment on the application of a niosomal form of anti-tumor medicine
The study of histological changes showed that encapsulation of the antitumor substance N-hydroxy-2-(2-(naphthalen-2-yl)-1H-indol-3-yl)-2-phenylacetamide in niosomes increases its cytotoxicity. This is due to the peculiarities of the phar-macokinetics of niosomal drugs. When the antitumor substance i...
Enregistré dans:
| Auteurs principaux: | , |
|---|---|
| Format: | Статья |
| Langue: | Russian |
| Publié: |
Stavropol State Medical University
2020
|
| Sujets: | |
| Accès en ligne: | https://dspace.ncfu.ru/handle/20.500.12258/11613 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
| Résumé: | The study of histological changes showed that encapsulation of the antitumor substance N-hydroxy-2-(2-(naphthalen-2-yl)-1H-indol-3-yl)-2-phenylacetamide in niosomes increases its cytotoxicity. This is due to the peculiarities of the phar-macokinetics of niosomal drugs. When the antitumor substance is encapsulated in niosomes, its metabolism is slower in the liver, and due to this the substance is in the peripheral blood for a longer time at higher concentrations compared to the introduction of the antitumor substance in its pure form |
|---|