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Spirocyclic thienopyrimidines: synthesis, new rearrangement under vilsmeier conditions and in silico prediction of anticancer activity

Aim. To find novel anticancer lead molecules among easily available spiro-fused thieno[2,3-d] pyrimidines. Methods. Organic synthesis, spectral methods and molecular docking. Results. New spiro heterocycles were synthesized by condensation of 2-aminothiophene-3-carbonitriles with cyclic ketones via...

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Autori principali: Dotsenko, V. V., Доценко, В. В.
Natura: Статья
Lingua:English
Pubblicazione: National Academy of Sciences of Ukraine 2020
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Accesso online:https://dspace.ncfu.ru/handle/20.500.12258/14298
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