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Synthesis of 2-(1H-Indol-2-yl)acetamides via bronsted acid-assisted cyclization cascade

Synthesis of 2-(1H-Indol-2-yl)acetamides via bronsted acid-assisted cyclization cascade

An efficient and straightforward Bronsted-acid mediated cascade process was developed, involving cyclization of readily available beta-ketonitriles into 2-aminofurans, and their subsequent recyclization into 2-(1H-indol-2-yl)acetamides is developed. This synthetic route opens a new avenue for an exp...

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Autori principali: Aksenov, N. A., Аксенов, Н. А., Aksenov, D. A., Аксенов, Д. А., Skomorokhov, A. A., Скоморохов, А. А., Prityko, L. A., Притыко, Л. А., Aksenov, A. V., Аксенов, А. В., Griaznov, G. D., Грязнов, Г. Д., Rubin, M. A., Рубин, М. А.
Natura: Статья
Lingua:English
Pubblicazione: AMER CHEMICAL SOC 2020
Soggetti:
2'-aminochalcones
Efficient
Michael addition
Histone
Discovery
Indoles
Reduction
Inhibitory-activity
Nitrostyrenes
Route
Accesso online:https://dspace.ncfu.ru/handle/20.500.12258/14565
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https://dspace.ncfu.ru/handle/20.500.12258/14565

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