Preparation of spiro[indole-3,5′-isoxazoles] via Grignard conjugate addition/spirocyclization sequence

A highly efficient one-pot procedure combining conjugate addition of Grignard reagents to (2-nitroalkenyl)indoles and sub-sequent Brønsted acid-assisted spirocyclization allowed for preparation of 4′H-spiro[indole-3,5′-isoxazoles] in a diastereomerically selective fashion. Utilization of alkyl Grign...

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Huvudupphovsmän:	Aksenov, A. V., Аксенов, А. В., Aksenov, D. A., Аксенов, Д. А., Aksenov, N. A., Аксенов, Н. А., Skomorokhov, A. A., Скоморохов, А. А., Aleksandrova, E. V., Александрова, Е. В., Rubin, M. A., Рубин, М. А.
Materialtyp:	Статья
Språk:	English
Publicerad:	Royal Society of Chemistry 2021
Ämnen:	Addition reactions Reagents Alkyl-substituted derivatives Polycyclic aromatic hydrocarbons
Länkar:	https://dspace.ncfu.ru/handle/20.500.12258/14853
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https://dspace.ncfu.ru/handle/20.500.12258/14853

Preparation of spiro[indole-3,5′-isoxazoles] via Grignard conjugate addition/spirocyclization sequence

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