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[3 + 2]-Annulation of pyridinium ylides with 1-chloro-2-nitrostyrenes unveils a tubulin polymerization inhibitor

[3 + 2]-Annulation of pyridinium ylides with 1-chloro-2-nitrostyrenes unveils a tubulin polymerization inhibitor

Indolizines and pyrazolo[1,5-a]pyridines were prepared via [3 + 2]-cycloaddition of pyridinium ylides to 1-chloro-2-nitrostyrenes. The synthesized molecules were evaluated for antiproliferative activities against a BE(2)-C neuroblastoma cell line with several compounds decreasing the viability of ca...

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Autori principali: Aksenov, A. V., Аксенов, А. В., Arutiunov, N. A., Арутюнов, Н. А., Kirilov, N. K., Кирилов, Н. К., Aksenov, D. A., Аксенов, Д. А., Grishin, I. Y., Гришин, И. Ю., Aksenov, N. A., Аксенов, Н. А., Rubin, M. A., Рубин, М. А.
Natura: Статья
Lingua:English
Pubblicazione: Royal Society of Chemistry 2021
Soggetti:
Indolizines
Pyrazolo[1,5-a]pyridines
Indolizine 9db
Anticancer agents
Accesso online:https://dspace.ncfu.ru/handle/20.500.12258/18098
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https://dspace.ncfu.ru/handle/20.500.12258/18098

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