Direct conversion of 3-(2-nitroethyl)-1H-indoles into 2-(1H-indol-2-yl)acetonitriles

The recently discovered [4+1]-spirocyclization of nitroalkenes to indoles provided a convenient new approach to 2-(1H-indol-2-yl)acetonitriles. However, this reaction was complicated by the formation of inert 3-(2-nitroethyl)-1H-indole byproducts. Herein, we offer a workaround this problem that allo...

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Главные авторы:	Aksenov, A. V., Аксенов, А. В., Aksenov, N. A., Аксенов, Н. А., Aleksandrova, E. V., Александрова, Е. В., Aksenov, D. A., Аксенов, Д. А., Grishin, I. Y., Гришин, И. Ю., Rubin, M. A., Рубин, М. А.
Формат:	Статья
Язык:	English
Опубликовано:	MDPI 2021
Темы:	Nitroalkanes Cascade transformations Heterocycles 1,2-alkyl shift Rearrangements
Online-ссылка:	https://dspace.ncfu.ru/handle/20.500.12258/18235
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id	ir-20.500.12258-18235
record_format	dspace
spelling	ir-20.500.12258-182352025-02-12T14:08:00Z Direct conversion of 3-(2-nitroethyl)-1H-indoles into 2-(1H-indol-2-yl)acetonitriles Aksenov, A. V. Аксенов, А. В. Aksenov, N. A. Аксенов, Н. А. Aleksandrova, E. V. Александрова, Е. В. Aksenov, D. A. Аксенов, Д. А. Grishin, I. Y. Гришин, И. Ю. Rubin, M. A. Рубин, М. А. Nitroalkanes Cascade transformations Heterocycles 1,2-alkyl shift Rearrangements The recently discovered [4+1]-spirocyclization of nitroalkenes to indoles provided a convenient new approach to 2-(1H-indol-2-yl)acetonitriles. However, this reaction was complicated by the formation of inert 3-(2-nitroethyl)-1H-indole byproducts. Herein, we offer a workaround this problem that allows for effective transformation of the unwanted byproducts into acetonitrile target molecules. 2021-11-08T14:27:28Z 2021-11-08T14:27:28Z 2021 Статья Aksenov, A.V., Aksenov, N.A., Aleksandrova, E.V., Aksenov, D.A., Grishin, I.Yu., Sorokina, E.A., Wenger, A., Rubin, M. Direct conversion of 3-(2-nitroethyl)-1H-indoles into 2-(1H-indol-2-yl)acetonitriles // Molecules, - 2021. - Том 26. - Выпуск 20. - Номер статьи 6132. - DOI: 10.3390/molecules26206132 http://hdl.handle.net/20.500.12258/18235 en Molecules application/pdf application/pdf MDPI
institution	СКФУ
collection	Репозиторий
language	English
topic	Nitroalkanes Cascade transformations Heterocycles 1,2-alkyl shift Rearrangements
spellingShingle	Nitroalkanes Cascade transformations Heterocycles 1,2-alkyl shift Rearrangements Aksenov, A. V. Аксенов, А. В. Aksenov, N. A. Аксенов, Н. А. Aleksandrova, E. V. Александрова, Е. В. Aksenov, D. A. Аксенов, Д. А. Grishin, I. Y. Гришин, И. Ю. Rubin, M. A. Рубин, М. А. Direct conversion of 3-(2-nitroethyl)-1H-indoles into 2-(1H-indol-2-yl)acetonitriles
description	The recently discovered [4+1]-spirocyclization of nitroalkenes to indoles provided a convenient new approach to 2-(1H-indol-2-yl)acetonitriles. However, this reaction was complicated by the formation of inert 3-(2-nitroethyl)-1H-indole byproducts. Herein, we offer a workaround this problem that allows for effective transformation of the unwanted byproducts into acetonitrile target molecules.
format	Статья
author	Aksenov, A. V. Аксенов, А. В. Aksenov, N. A. Аксенов, Н. А. Aleksandrova, E. V. Александрова, Е. В. Aksenov, D. A. Аксенов, Д. А. Grishin, I. Y. Гришин, И. Ю. Rubin, M. A. Рубин, М. А.
author_facet	Aksenov, A. V. Аксенов, А. В. Aksenov, N. A. Аксенов, Н. А. Aleksandrova, E. V. Александрова, Е. В. Aksenov, D. A. Аксенов, Д. А. Grishin, I. Y. Гришин, И. Ю. Rubin, M. A. Рубин, М. А.
author_sort	Aksenov, A. V.
title	Direct conversion of 3-(2-nitroethyl)-1H-indoles into 2-(1H-indol-2-yl)acetonitriles
title_short	Direct conversion of 3-(2-nitroethyl)-1H-indoles into 2-(1H-indol-2-yl)acetonitriles
title_full	Direct conversion of 3-(2-nitroethyl)-1H-indoles into 2-(1H-indol-2-yl)acetonitriles
title_fullStr	Direct conversion of 3-(2-nitroethyl)-1H-indoles into 2-(1H-indol-2-yl)acetonitriles
title_full_unstemmed	Direct conversion of 3-(2-nitroethyl)-1H-indoles into 2-(1H-indol-2-yl)acetonitriles
title_sort	direct conversion of 3-(2-nitroethyl)-1h-indoles into 2-(1h-indol-2-yl)acetonitriles
publisher	MDPI
publishDate	2021
url	https://dspace.ncfu.ru/handle/20.500.12258/18235
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Direct conversion of 3-(2-nitroethyl)-1H-indoles into 2-(1H-indol-2-yl)acetonitriles

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