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Electrophilically activated nitroalkanes in the synthesis of substituted 1,3,4-oxadiazoles from amino acid derivatives

Electrophilically activated nitroalkanes in the synthesis of substituted 1,3,4-oxadiazoles from amino acid derivatives

Novel preparative approach for the synthesis of alkylamines with 1,3,4-oxadiazole heterocyclic substituent is described. This method is based on unusual cascade transformation involving formal (4+1) cyclocondensation of hydrazides of amino acids with nitroalkanes electrophilically activated in the p...

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Huvudupphovsmän: Aksenov, A. V., Аксенов, А. В., Kirilov, N. K., Кирилов, Н. К., Aksenov, N. A., Аксенов, Н. А., Arutiunov, N. A., Арутюнов, Н. А., Aksenov, D. A., Аксенов, Д. А., Rubin, M. A., Рубин, М. А.
Materialtyp: Статья
Språk:English
Publicerad: Springer 2022
Ämnen:
1,3,4-oxadiazoles
1,3,4-thiadiazoles
Amino acids
Brønsted acid catalysis
Cascade reaction
Nitroalkanes
Nucleophilic cycloaddition
Semicarbazides
Länkar:https://dspace.ncfu.ru/handle/20.500.12258/18827
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https://dspace.ncfu.ru/handle/20.500.12258/18827

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