Synthesis and Aminomethylation of 2-Amino-4-(2-chlorophenyl)-6-(dicyanomethyl)-1,4-dihydropyridine-3,5-dicarbonitrile N-Methylmorpholinium Salt

Synthesis and Aminomethylation of 2-Amino-4-(2-chlorophenyl)-6-(dicyanomethyl)-1,4-dihydropyridine-3,5-dicarbonitrile N-Methylmorpholinium Salt

Sequential reaction of 2-chlorobenzaldehyde, cyanothioacetamide, and malononitrile dimer in the presence of an excess of N-methylmorpholine resulted in the formation of N-methylmorphlinium salt of 2-amino-4-(2-chlorophenyl)-6-(dicyanomethyl)-1,4-dihydropyridine-3,5-dicarbonitrile. The resulting salt...

Descripció completa

Guardat en:

Dades bibliogràfiques
Autors principals:	Dotsenko, V. V., Доценко, В. В., Aksenov, N. A., Аксенов, Н. А., Aksenova, I. V., Аксенова, И. В.
Format:	Статья
Idioma:	English
Publicat:	Pleiades journals 2022
Matèries:	1,4-dihydropyridines 2-aminopropene-1,1,3-tricarbonitrile Aminomethylation Calculated biological activity Cyanothioacetamide
Accés en línia:	https://dspace.ncfu.ru/handle/20.500.12258/21528
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars

Synthesis and Aminomethylation of 6-Amino-2-(dicyanomethylene)-4-phenyl-1,2-dihydropyridine-3,5-dicarbonitrile Morpholinium Salt
per: Dotsenko, V. V., et al.
Publicat: (2021)

New methods of synthesis, structure and aminomethylation of 4-imino-2-(dicyanomethylene)-3-azaspiro[5.5]undecane-1,5-dicarbonitrile
per: Dotsenko, V. V., et al.
Publicat: (2021)

New Heterocyclization Reactions with Malononitrile Dimer
per: Dotsenko, V. V., et al.
Publicat: (2024)

Mannich Reaction Involving 6-Amino-4-methyl-2-(thio)oxo-1,2-dihydropyridine-3,5-dicarbonitriles
per: Strelkov, V. D., et al.
Publicat: (2023)

Synthesis, structure, and analgesic activity of 4-(5-Cyano-{4-(fur-2-yl)-1,4-dihydropyridin-3-yl}carboxamido)benzoic acids ethyl esters
per: Dotsenko, V. V., et al.
Publicat: (2022)

Empirical determination of the degree of analgesic activity of some new 3-aminothieno[2,3-b]pyridines and 1,4-dihydropyridines based on a complex criterion
per: Dotsenko, V. V., et al.
Publicat: (2023)

New 4-(2-Furyl)-1,4-dihydronicotinonitriles and 1,4,5,6-Tetrahydronicotinonitriles: synthesis, structure, and analgesic activity
per: Dotsenko, V. V., et al.
Publicat: (2021)

1,6-Diamino-2-oxopyridine-3,5-dicarbonitrile Derivatives in the Mannich Reaction
per: Dotsenko, V. V., et al.
Publicat: (2021)

7-Aryl-3-(hydroxymethyl)-5-oxo-1,2,3,5-tetrahydro[1,2,4]triazolo[1,5-a]pyridine-6,8-dicarbonitriles: Synthesis and Predicted Biological Activity
per: Dotsenko, V. V., et al.
Publicat: (2022)

Reaction of ethoxymethylenemalonate with cyanothioacetamide in the presence of triethylamine: formation of 1,5-diamino-2,4-dicyano-5-thioxopenta-1,3-diene-1-thiolate and unexpected aminomethylation result
per: Dotsenko, V. V., et al.
Publicat: (2020)

STUDY OF ANTI-INFLAMMATORY AND ANTINOCICEPTIVE PROPERTIES OF NEW DERIVATIVES OF CONDENSED 3-AMINOTHIENO[2,3-b]PYRIDINES AND 1,4-DIHYDROPYRIDINES
per: Dotsenko, V. V., et al.
Publicat: (2023)

New Hybrid Molecules Based on Sulfur-Containing Nicotinonitriles: Synthesis, Analgesic Activity in Acetic Acid-Induced Writhing Test, and Molecular Docking Studies
per: Dotsenko, V. V., et al.
Publicat: (2022)

Synthesis and In vivo Evaluation of Hepatoprotective Effects of Novel Sulfur-Containing 1,4-Dihydropyridines and 1,2,3,4-Tetrahydropyridines
per: Dotsenko, V. V., et al.
Publicat: (2023)

α-Amino acid-assisted autoxidation of naphthalene proton sponge affording 1,4-naphthoquinone nitrogen derivatives
per: Demidov, O. P., et al.
Publicat: (2023)

Reactions of malononitrile dimer with isothiocyanates
per: Dotsenko, V. V., et al.
Publicat: (2021)

Aminomethylation of Guareschi imides: synthesis of 2,4-dioxo-1H,5H-3,7-spiro[diazabicyclo[3.3.1]nonane-9,4'-piperidine]-1,5-dicarbonitriles
per: Dotsenko, V. V., et al.
Publicat: (2018)

Oxidation of 4,6-Dimethyl-2-thioxo-1,2-dihydropyridine-3-carbonitriles with Potassium Ferricyanide: Synthesis and Molecular Docking of Bis(pyrid-2-yl) Disulfides
per: Dotsenko, V. V., et al.
Publicat: (2024)

Reaction of 5-Amino-3-(cyanomethyl)-1H-pyrazole-4-carbonitrile with Hydroxycyclohexanones
per: Dotsenko, V. V., et al.
Publicat: (2019)

Some new reactions and properties of xanthane hydride (5-amino-1,2,4-dithiazole-3-thione)
per: Dotsenko, V. V., et al.
Publicat: (2018)

Electrophilically activated nitroalkanes in the synthesis of substituted 1,3,4-oxadiazoles from amino acid derivatives
per: Aksenov, A. V., et al.
Publicat: (2022)

Synthesis and structure of new 3,7-diazabicyclo[3.3.1]nonane derivatives
per: Dotsenko, V. V., et al.
Publicat: (2018)

Synthesis and Structure of (2E)-3-Aryl(hetaryl)-2-[5-bromo-4-aryl(hetaryl)-1,3-thiazol-2-yl]acrylonitriles
per: Dotsenko, V. V., et al.
Publicat: (2021)

Molecular insights into codon usage analysis of mitochondrial fission and fusion gene: relevance to neurodegenerative diseases
per: Baklanov, I. S., et al.
Publicat: (2024)

Synthesis and some properties of new 5-Hydroxy-2-[(hetarylthio)methyl]-4H-pyran-4-ones
per: Dotsenko, V. V., et al.
Publicat: (2021)

Nucleophilic dearomatization of 3-nitrobenzofurans by the action of 2-(1-arylethylidene)malononitriles
per: Demidov, O. P., et al.
Publicat: (2021)

Synthesis of imidazo[1,5-a]pyridines via cyclocondensation of 2-(aminomethyl)pyridines with electrophilically activated nitroalkanes
per: Aksenov, D. A., et al.
Publicat: (2020)

Synthesis and properties of 4,6-Dimethyl-5-pentyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile and 3-Amino-4,6-dimethyl-5-pentylthieno[2,3-b]pyridines
per: Dotsenko, V. V., et al.
Publicat: (2019)

7-(2-Aryl-1-cyanovinyl)-1,2,3,4-tetrahydropyrazolo[1,5-a][1,3,5]triazine-8-carbonitriles: Synthesis and Biological Activity
per: Dotsenko, V. V., et al.
Publicat: (2023)

Introduction of tetrazol-1-yl and 5-methyltetrazol-1-yl substituents in the phenyl ring of dibenzo-18-crown-6
per: Aksenov, N. A., et al.
Publicat: (2018)

A convenient synthesis of furo[3,2-c]pyran-3-carboxylates from 3-bromo-3-nitroacrylates
per: Dotsenko, V. V., et al.
Publicat: (2022)

Synthesis and analgesic activity of new heterocyclic cyanothioacetamide derivatives
per: Dotsenko, V. V., et al.
Publicat: (2021)

Preparation of 1,3,4-oxadiazoles and 1,3,4-thiadiazoles via chemoselective сyclocondensation of electrophilically activated nitroalkanes to (thio)semicarbazides or thiohydrazides
per: Aksenov, N. A., et al.
Publicat: (2020)

New Heterocyclisation Reactions of 5-Amino-3-(cyanomethyl)-1H-pyrazole-4-carbonitrile with Some 1,3-Dielectrophilic Agents
per: Dotsenko, V. V., et al.
Publicat: (2022)

Пожарная безопасность объектов защиты классов Ф1-Ф4 учебно-справочное пособие
per: Собурь, С. В.

1-й отдельный стрелковый корпус на рубеже Смыков-Григорополисская
per: Карташев, А. В.
Publicat: (2022)

Unusual cyclization of N-imidazolyl quinone imines with the formation of thiadiazole ring and its subsequent recyclization
per: Demidov, O. P., et al.
Publicat: (2022)

EVALUATION OF HEMATOTOXICITY OF NEW DERIVATIVES OF CONDENSED 3-AMINOTHIENO[2,3-b]PYRIDINES AND 1,4-DIHYDROPYRIDINES WITH HIGH ANALGESIC ACTIVITY
per: Dotsenko, V. V., et al.
Publicat: (2024)

Alkyl 4-Aryl-6-amino-7- phenyl-3-(phenylimino)-4,7-dihydro- 3H-[1,2]dithiolo[3,4-b]pyridine-5-carboxylates: Synthesis and Agrochemical Studies
per: Dotsenko, V. V., et al.
Publicat: (2023)

Synthesis of new functionalized 3,7-diazabicyclo[3.3.1]nonanes by aminomethylation of the Guareschi imides
per: Dotsenko, V. V., et al.
Publicat: (2018)

Информационные технологии в управлении образовательными учреждениями
per: Захарова И. Г.