Mannich Reaction Involving 6-Amino-4-methyl-2-(thio)oxo-1,2-dihydropyridine-3,5-dicarbonitriles

Mannich Reaction Involving 6-Amino-4-methyl-2-(thio)oxo-1,2-dihydropyridine-3,5-dicarbonitriles

The reaction of (1-ethoxyethylidene)malononitrile with cyanoacetamide or cyanothioacetamide has yielded 6-amino-4-methyl-2-(thio)oxo-1,2-dihydropyridine-3,5-dicarbonitriles. The resulting pyridine derivatives enter into the aminomethylation reaction with an excess of formaldehyde and primary amines...

Deskribapen osoa

Gorde:

Xehetasun bibliografikoak
Egile Nagusiak:	Strelkov, V. D., Стрелков, В. Д., Dotsenko, V. V., Доценко, В. В., Aksenov, N. A., Аксенов, Н. А., Aksenova, I. V., Аксенова, И. В.
Formatua:	Статья
Hizkuntza:	English
Argitaratua:	2023
Gaiak:	2,4-D antidotes Pyrido[1,2-a][1,3,5]triazines 2-aminopyridines 2-oxopyridines Aminomethylation Mannich reaction Corrosion inhibitors Nicotinonitriles
Sarrera elektronikoa:	https://dspace.ncfu.ru/handle/20.500.12258/25524
Etiketak:	Etiketa erantsi Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak

Synthesis and analgesic activity of new heterocyclic cyanothioacetamide derivatives
nork: Dotsenko, V. V., et al.
Argitaratua: (2021)

Synthesis and Aminomethylation of 6-Amino-2-(dicyanomethylene)-4-phenyl-1,2-dihydropyridine-3,5-dicarbonitrile Morpholinium Salt
nork: Dotsenko, V. V., et al.
Argitaratua: (2021)

1,6-Diamino-2-oxopyridine-3,5-dicarbonitrile Derivatives in the Mannich Reaction
nork: Dotsenko, V. V., et al.
Argitaratua: (2021)

New Heterocyclization Reactions with Malononitrile Dimer
nork: Dotsenko, V. V., et al.
Argitaratua: (2024)

Synthesis and some properties of new 5-Hydroxy-2-[(hetarylthio)methyl]-4H-pyran-4-ones
nork: Dotsenko, V. V., et al.
Argitaratua: (2021)

Synthesis and Aminomethylation of 2-Amino-4-(2-chlorophenyl)-6-(dicyanomethyl)-1,4-dihydropyridine-3,5-dicarbonitrile N-Methylmorpholinium Salt
nork: Dotsenko, V. V., et al.
Argitaratua: (2022)

Reactions of malononitrile dimer with isothiocyanates
nork: Dotsenko, V. V., et al.
Argitaratua: (2021)

A facile synthesis of 1-oxo-pyrrolo[2,1-a]isoquinolines
nork: Aksenov, A. V., et al.
Argitaratua: (2018)

A facile synthesis of 1-oxo-pyrrolo[2,1-a]isoquinolines
nork: Aksenov, A. V., et al.
Argitaratua: (2018)

New methods of synthesis, structure and aminomethylation of 4-imino-2-(dicyanomethylene)-3-azaspiro[5.5]undecane-1,5-dicarbonitrile
nork: Dotsenko, V. V., et al.
Argitaratua: (2021)

Oxidation of 4,6-Dimethyl-2-thioxo-1,2-dihydropyridine-3-carbonitriles with Potassium Ferricyanide: Synthesis and Molecular Docking of Bis(pyrid-2-yl) Disulfides
nork: Dotsenko, V. V., et al.
Argitaratua: (2024)

Oxidation of 2-Cyanothioacrylamides with Sodium Nitrite in Acidic Medium
nork: Dotsenko, V. V., et al.
Argitaratua: (2022)

Histological studies of organs in experiment on the application of a niosomal form of anti-tumor medicine
nork: Aksenov, A. V., et al.
Argitaratua: (2020)

7-Aryl-3-(hydroxymethyl)-5-oxo-1,2,3,5-tetrahydro[1,2,4]triazolo[1,5-a]pyridine-6,8-dicarbonitriles: Synthesis and Predicted Biological Activity
nork: Dotsenko, V. V., et al.
Argitaratua: (2022)

Empirical determination of the degree of analgesic activity of some new 3-aminothieno[2,3-b]pyridines and 1,4-dihydropyridines based on a complex criterion
nork: Dotsenko, V. V., et al.
Argitaratua: (2023)

Crystal structure and properties of new benzimidazopyrido[2,3-b]indole-6-carbonitriles
nork: Demidov, O. P., et al.
Argitaratua: (2024)

Unexpected result of thiophosphorylation of 6-aminopyrano[2,3-c]pyrazole-5-carbonitrile derivative
nork: Dotsenko, V. V., et al.
Argitaratua: (2019)

Synthesis, structure, and biological activity of 2,6-diazido-4-methylnicotinonitrile derivatives
nork: Aksenov, N. A., et al.
Argitaratua: (2018)

(2E,2′E)-2,2′-(1,2,4-Thiadiazole-3,5-diyl)bis[3-arylacrylonitriles]: Synthesis and Antidote Activity Towards 2,4-D Herbicide
nork: Dotsenko, V. V., et al.
Argitaratua: (2023)

Mn-mediated sequential three-component domino Knoevenagel/cyclization/Michael addition/oxidative cyclization reaction towards annulated imidazo[1,2-a]pyridines
nork: Aksenov, A. V., et al.
Argitaratua: (2019)

Nucleophilic dearomatization of 3-nitrobenzofurans by the action of 2-(1-arylethylidene)malononitriles
nork: Demidov, O. P., et al.
Argitaratua: (2021)

Synthesis and structure of new 3,7-diazabicyclo[3.3.1]nonane derivatives
nork: Dotsenko, V. V., et al.
Argitaratua: (2018)

Codon Usage and Context Analysis of Genes Modulated during SARS-CoV-2 Infection and Dental Inflammation
nork: Rzhepakovsky, I. V., et al.
Argitaratua: (2023)

Synthesis and properties of 4,6-Dimethyl-5-pentyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile and 3-Amino-4,6-dimethyl-5-pentylthieno[2,3-b]pyridines
nork: Dotsenko, V. V., et al.
Argitaratua: (2019)

Some new reactions and properties of xanthane hydride (5-amino-1,2,4-dithiazole-3-thione)
nork: Dotsenko, V. V., et al.
Argitaratua: (2018)

Divergent Transformations of 2-Nitro-1H-benzo[f]chromenes in Reactions with Alkylidenemalononitriles: Access to Naphtho[2,1-b]furans via Base-Mediated Pyran Ring Contraction
nork: Demidov, O. P., et al.
Argitaratua: (2024)

Unusual cyclization of N-imidazolyl quinone imines with the formation of thiadiazole ring and its subsequent recyclization
nork: Demidov, O. P., et al.
Argitaratua: (2022)

Recent advances in the chemistry of thieno[2,3-b]pyridines 1. Methods of synthesis of thieno[2,3-b]pyridines
nork: Dotsenko, V. V., et al.
Argitaratua: (2020)

Synthesis and Structure of (2E)-3-Aryl(hetaryl)-2-[5-bromo-4-aryl(hetaryl)-1,3-thiazol-2-yl]acrylonitriles
nork: Dotsenko, V. V., et al.
Argitaratua: (2021)

Synthesis and biological activity of 8-(dialkylamino)-3-aryl-6-oxo-2,4-dicyanobicyclo[3.2.1]octane-2,4-dicarboxylic acids diethyl esters
nork: Dotsenko, V. V., et al.
Argitaratua: (2020)

Synthesis of thiazolo[3,2-a]pyridines via an unusual Mannich-type cyclization
nork: Dotsenko, V. V., et al.
Argitaratua: (2018)

Electrochemical Oxidation of 3-Aryl-2-cyanothioacrylamides
nork: Dotsenko, V. V., et al.
Argitaratua: (2023)

A novel QCA circuit-switched network with power dissipation analysis for nano communication applications
nork: Lyakhov, P. A., et al.
Argitaratua: (2023)

Direct conversion of 3-(2-nitroethyl)-1H-indoles into 2-(1H-indol-2-yl)acetonitriles
nork: Aksenov, A. V., et al.
Argitaratua: (2021)

Michael addition of amines to sterically crowded ortho-benzoquinone completed with unprecedented 1,2-shift of a tert-butyl group
nork: Demidov, O. P., et al.
Argitaratua: (2021)

New Azepine-Furan Spirocyclic Structures in the Reaction of 4-Aroyl-1,2-dihydrobenzo[d]azepines and 2-Aroyl-4,5-dihydrophenanthreno[1,2-d]azepine with Formaldehyde
nork: Demidov, O. P., et al.
Argitaratua: (2021)

Reactions of 2-Nitro-1H-benzo[f]chromenes and 3-Nitro-1-benzofurans with Nucleophiles
nork: Demidov, O. P., et al.
Argitaratua: (2023)

Synthesis and In vivo Evaluation of Hepatoprotective Effects of Novel Sulfur-Containing 1,4-Dihydropyridines and 1,2,3,4-Tetrahydropyridines
nork: Dotsenko, V. V., et al.
Argitaratua: (2023)

β-Carbolines as intermediates in indirect heteroarylation of tryptamines exemplified by the synthesis of 2-pyrazolyltryptamines
nork: Demidov, O. P., et al.
Argitaratua: (2023)

N-Hydroxymethylation of 3-Aryl-2-cyanoprop-2-enethioamides
nork: Dotsenko, V. V., et al.
Argitaratua: (2020)