Synthesis of β-Carbolines with Electrocyclic Cyclization of 3-Nitrovinylindoles

Synthesis of β-Carbolines with Electrocyclic Cyclization of 3-Nitrovinylindoles

The β-carboline motif is common in drug discovery and among numerous biologically active natural products. However, its synthetic preparation relies on multistep sequences and heavily depends on the type of substitution required in the core of the desired β-carboline target. Herein, we demonstrate t...

Полное описание

Сохранить в:

Библиографические подробности
Главные авторы:	Aksenov, N. A., Аксенов, Н. А., Arutiunov, N. A., Арутюнов, Н. А., Aksenov, A. V., Аксенов, А. В., Kirilov, N. K., Кирилов, Н. К., Aksenova, I. V., Аксенова, И. В., Aksenov, D. A., Аксенов, Д. А., Aleksandrova, E. V., Александрова, Е. В., Rubin, M. A., Рубин, М. А.
Формат:	Статья
Язык:	English
Опубликовано:	2023
Темы:	Beta-carboline Indole Electrocyclization Harmane Heterocycle Norharmane
Online-ссылка:	https://dspace.ncfu.ru/handle/20.500.12258/25549
Метки:	Добавить метку Нет меток, Требуется 1-ая метка записи!

Схожие документы

Nitrovinylindoles as Heterotrienes: Electrocyclic Cyclization En Route to β-Carbolines: Total Synthesis of Alkaloids Norharmane, Harmane, and Eudistomin N
Автор: Aksenov, N. A., и др.
Опубликовано: (2022)

Synthesis of chromenoimidazocarbolines by a reaction of quaternary iminium salts with o-hydroxybenzaldehydes
Автор: Aksenov, A. V., и др.
Опубликовано: (2018)

Synthesis of chromenoimidazocarbolines by a reaction of quaternary iminium salts with o-hydroxybenzaldehydes
Автор: Aksenov, A. V., и др.
Опубликовано: (2018)

β-Carbolines as intermediates in indirect heteroarylation of tryptamines exemplified by the synthesis of 2-pyrazolyltryptamines
Автор: Demidov, O. P., и др.
Опубликовано: (2023)

Reaction of 5-Amino-3-(cyanomethyl)-1H-pyrazole-4-carbonitrile with Hydroxycyclohexanones
Автор: Dotsenko, V. V., и др.
Опубликовано: (2019)

Mn-mediated sequential three-component domino Knoevenagel/cyclization/Michael addition/oxidative cyclization reaction towards annulated imidazo[1,2-a]pyridines
Автор: Aksenov, A. V., и др.
Опубликовано: (2019)

Unexpected cyclization ortho-nitrochalcones into 2-alkylideneindolin-3-ones
Автор: Aksenov, N. A., и др.
Опубликовано: (2020)

A New, Convenient Way to Fully Substituted α,β-Unsaturated γ-Hydroxy Butyrolactams
Автор: Aksenov, A. V., и др.
Опубликовано: (2023)

Modeling stages of domino reaction of thiopyrano[4,3-b]indole-3(5H)-thiones and dimethyl acetylenedicarboxylate: a new synthetic route to γ-carbolines with thione group
Автор: Demidov, O. P., и др.
Опубликовано: (2024)

Phytosterols: from preclinical evidence to potential clinical applications
Автор: Orobinskaya, V. N., и др.
Опубликовано: (2021)

Unexpected cyclization of 2-(2-aminophenyl)indoles with nitroalkenes to furnish indolo[3,2-: C] quinolines
Автор: Aksenov, A. V., и др.
Опубликовано: (2018)

Synthesis of 11H-indolo[3,2-c]quinolines by SnCl4-catalyzed cyclization of indole-3-carbaldehyde oximes
Автор: Aksenov, N. A., и др.
Опубликовано: (2020)

Modern trends of organic chemistry in russian universities
Автор: Aksenov, A. V., и др.
Опубликовано: (2018)

Introduction of tetrazol-1-yl and 5-methyltetrazol-1-yl substituents in the phenyl ring of dibenzo-18-crown-6
Автор: Aksenov, N. A., и др.
Опубликовано: (2018)

Modern trends of organic chemistry in russian universities
Автор: Aksenov, A. V., и др.
Опубликовано: (2018)

Oxidative Cyclization of 4-(2-Aminophenyl)-4-oxo-2-phenylbutanenitriles into 2-(3-Oxoindolin-2-ylidene)acetonitriles
Автор: Aksenov, N. A., и др.
Опубликовано: (2022)

Synthesis of 2-(1H-Indol-2-yl)acetamides via bronsted acid-assisted cyclization cascade
Автор: Aksenov, N. A., и др.
Опубликовано: (2020)

New photochromic indoline spiropyrans containing cationic substituent in the 2H-chromene moiety
Автор: Aksenov, N. A., и др.
Опубликовано: (2018)

Design, Synthesis, and Screening of Pyridothieno[3,2- b ]indole and Pyridothieno[3,2- c ]cinnoline Derivatives as Potential Biologically Active Molecules
Автор: Aksenov, N. A., и др.
Опубликовано: (2022)

Study of the Magnesium Comenate Structure, Its Neuroprotective and Stress-Protective Activity
Автор: Aksenov, N. A., и др.
Опубликовано: (2023)

On the structure of zinc(II) coordination compounds with l-histidine
Автор: Aksenov, N. A., и др.
Опубликовано: (2020)

Structure and properties of europium (III) triaquatriglycinate chloride
Автор: Aksenov, N. A., и др.
Опубликовано: (2020)

Synthesis of 4-(pyrazol-1-yl)pyrimidines from 4-hydrazinopyrimidines and investigation of their structure and some chemical properties
Автор: Aksenov, N. A., и др.
Опубликовано: (2024)

Preparation of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2: H -pyrrol-2-ones via base-assisted cyclization of 3-cyanoketones
Автор: Aksenov, N. A., и др.
Опубликовано: (2021)

Dihydro-2: H -thiopyran-3(4 H)-one-1,1-dioxide-a versatile building block for the synthesis of new thiopyran-based heterocyclic systems
Автор: Dotsenko, V. V., и др.
Опубликовано: (2018)

A facile synthesis of 1-oxo-pyrrolo[2,1-a]isoquinolines
Автор: Aksenov, A. V., и др.
Опубликовано: (2018)

Domino reactions of 1-substituted N-(cyanomethyl)isoquinolinium salts with salicylic aldehydes
Автор: Aksenov, A. V., и др.
Опубликовано: (2018)

A facile synthesis of 1-oxo-pyrrolo[2,1-a]isoquinolines
Автор: Aksenov, A. V., и др.
Опубликовано: (2018)

Reaction of benzyne with 1,2,3,4-tetrahydroisoquinolines as an access to 1H-3-benzazepines
Автор: Aksenov, A. V., и др.
Опубликовано: (2018)

Reactions of 3,4-dihydroisoquinolines and dihydrothieno[3,2-c]pyridines with benzyne
Автор: Aksenov, A. V., и др.
Опубликовано: (2018)

Interaction of condensed tetrahydropyrido[4,3-d]pyrimidin-4-ones with dehydrobenzene – synthesis of 6-vinylpyrimidinones fused with five-membered heterocycle containing two or three heteroatoms
Автор: Aksenov, A. V., и др.
Опубликовано: (2018)

5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells
Автор: Aksenov, A. V., и др.
Опубликовано: (2018)

First synthesis of heterocyclic allenes-benzazecine derivatives
Автор: Aksenov, A. V., и др.
Опубликовано: (2018)

Three-component reaction of ketals, isonitriles, and trimethylsilyl azide
Автор: Aksenov, A. V., и др.
Опубликовано: (2018)

Histological studies of organs in experiment on the application of a niosomal form of anti-tumor medicine
Автор: Aksenov, A. V., и др.
Опубликовано: (2020)

The green chemistry paradigm in modern organic synthesis
Автор: Aksenov, A. V., и др.
Опубликовано: (2024)

A novel multi-component approach to the synthesis of pyrrolo[2,1-a] isoquinoline derivatives
Автор: Aksenov, A. V., и др.
Опубликовано: (2018)

A new series of acetohydroxamates shows in vitro and in vivo anticancer activity against melanoma
Автор: Aksenov, A. V., и др.
Опубликовано: (2019)

Electrophilically activated nitroalkanes in double annulation of [1,2,4]triazolo[4,3-a]quinolines and 1,3,4-oxadiazole rings
Автор: Aksenov, A. V., и др.
Опубликовано: (2021)

Electrophilically activated nitroalkanes in the synthesis of substituted 1,3,4-oxadiazoles from amino acid derivatives
Автор: Aksenov, A. V., и др.
Опубликовано: (2022)