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Targeted Synthesis of New 5-Phenyl-2-[(E)-Styryl]-1H-Pyrimidin-6-One Derivatives and Their Inhibitory Activity Toward SARS-CoV-2 Major (MPRO) and Papain-Like Proteases (PLPRO)

Targeted Synthesis of New 5-Phenyl-2-[(E)-Styryl]-1H-Pyrimidin-6-One Derivatives and Their Inhibitory Activity Toward SARS-CoV-2 Major (MPRO) and Papain-Like Proteases (PLPRO)

The use of the 5-phenyl-1H-pyrimidin-6-one scaffold in the search for biologically active compounds with antiviral activity based on the pyrimidin-4-one core present in endogenous substances and drugs was substantiated. The molecular activity and pharmacokinetic descriptors for styryl derivatives of...

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Bibliografische gegevens
Hoofdauteurs: Anenko, D. S., Аненко, Д. С.
Formaat: Статья
Taal:English
Gepubliceerd in: 2024
Onderwerpen:
Cyclocondensation
X-ray diffraction analysis
N-substituted pyrimidin-6(1H)-one
Pharmacokinetic descriptors
Powder x-ray diffraction
SARS-CoV-2 protease inhibitors
Styrylation
Online toegang:https://dspace.ncfu.ru/handle/20.500.12258/26581
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https://dspace.ncfu.ru/handle/20.500.12258/26581

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