Desymmetrization of cyclopropenes via the potassium-templated diastereoselective 7- exo- trig cycloaddition of tethered amino alcohols toward enantiopure cyclopropane-fused oxazepanones with antimycobacterial activity
A strain-release-driven, cation-templated intramolecular nucleophilic addition of tethered alkoxides to prochiral cyclopropenes is described. Employment of chiral β- and γ-amino alkoxides allowed for highly diastereoselective assembly of a small series of enantiopure cyclopropane-fused oxazepanones....
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| Главные авторы: | , , , |
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| Формат: | Статья |
| Язык: | English |
| Опубликовано: |
American Chemical Society
2018
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| Темы: | |
| Online-ссылка: | https://dspace.ncfu.ru:443/handle/20.500.12258/385 |
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