Synthesis of spiro[indole-3,5′-isoxazoles] with anticancer activity via a formal [4 + 1]-spirocyclization of nitroalkenes to indoles
An acid-assisted [4 + 1]-cycloaddition of indoles with nitrostyrenes affords 4′H-spiro[indole-3,5′-isoxazoles] in a diastereomerically pure form. Several of these spirocyclic molecules exhibit promising anticancer activity by reducing viability and inducing differentiation of neuroblastoma cells
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| Главные авторы: | , , , , , , , , , , , |
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| Формат: | Статья |
| Язык: | English |
| Опубликовано: |
American Chemical Society
2019
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| Темы: | |
| Online-ссылка: | https://dspace.ncfu.ru/handle/20.500.12258/5582 |
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