Anar al contingut
Synthesis of spiro[indole-3,5′-isoxazoles] with anticancer activity via a formal [4 + 1]-spirocyclization of nitroalkenes to indoles

Synthesis of spiro[indole-3,5′-isoxazoles] with anticancer activity via a formal [4 + 1]-spirocyclization of nitroalkenes to indoles

An acid-assisted [4 + 1]-cycloaddition of indoles with nitrostyrenes affords 4′H-spiro[indole-3,5′-isoxazoles] in a diastereomerically pure form. Several of these spirocyclic molecules exhibit promising anticancer activity by reducing viability and inducing differentiation of neuroblastoma cells

Guardat en:
Dades bibliogràfiques
Autors principals: Aksenov, A. V., Аксенов, А. В., Aksenov, D. A., Аксенов, Д. А., Arutiunov, N. A., Арутюнов, Н. А., Aksenov, N. A., Аксенов, Н. А., Aleksandrova, E. V., Александрова, Е. В., Rubin, M. A., Рубин, М. А.
Format: Статья
Idioma:English
Publicat: American Chemical Society 2019
Matèries:
Anticancer activity
Indoles
Nitroalkenes
Spirocyclization
Accés en línia:https://dspace.ncfu.ru/handle/20.500.12258/5582
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Internet

https://dspace.ncfu.ru/handle/20.500.12258/5582

Ítems similars