Synthesis of spiro[indole-3,5′-isoxazoles] with anticancer activity via a formal [4 + 1]-spirocyclization of nitroalkenes to indoles

An acid-assisted [4 + 1]-cycloaddition of indoles with nitrostyrenes affords 4′H-spiro[indole-3,5′-isoxazoles] in a diastereomerically pure form. Several of these spirocyclic molecules exhibit promising anticancer activity by reducing viability and inducing differentiation of neuroblastoma cells

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Autori principali:	Aksenov, A. V., Аксенов, А. В., Aksenov, D. A., Аксенов, Д. А., Arutiunov, N. A., Арутюнов, Н. А., Aksenov, N. A., Аксенов, Н. А., Aleksandrova, E. V., Александрова, Е. В., Rubin, M. A., Рубин, М. А.
Natura:	Статья
Lingua:	English
Pubblicazione:	American Chemical Society 2019
Soggetti:	Anticancer activity Indoles Nitroalkenes Spirocyclization
Accesso online:	https://www.scopus.com/record/display.uri?eid=2-s2.0-85067007191&origin=resultslist&sort=plf-f&src=s&st1=Synthesis+of+Spiro%5bindole-3%2c5%E2%80%B2-isoxazoles%5d+with+Anticancer+Activity+via+a+Formal+%5b4+%2b+1%5d-Spirocyclization+of+Nitroalkenes+to+Indoles&st2=&sid=0a6da1faec8406656ad1e7a9ab6c75b0&sot=b&sdt=b&sl=147&s=TITLE-ABS-KEY%28Synthesis+of+Spiro%5bindole-3%2c5%E2%80%B2-isoxazoles%5d+with+Anticancer+Activity+via+a+Formal+%5b4+%2b+1%5d-Spirocyclization+of+Nitroalkenes+to+Indoles%29&relpos=0&citeCnt=0&searchTerm= https://dspace.ncfu.ru/handle/20.500.12258/5582
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spelling	ir-20.500.12258-55822020-07-29T11:57:55Z Synthesis of spiro[indole-3,5′-isoxazoles] with anticancer activity via a formal [4 + 1]-spirocyclization of nitroalkenes to indoles Aksenov, A. V. Аксенов, А. В. Aksenov, D. A. Аксенов, Д. А. Arutiunov, N. A. Арутюнов, Н. А. Aksenov, N. A. Аксенов, Н. А. Aleksandrova, E. V. Александрова, Е. В. Rubin, M. A. Рубин, М. А. Anticancer activity Indoles Nitroalkenes Spirocyclization An acid-assisted [4 + 1]-cycloaddition of indoles with nitrostyrenes affords 4′H-spiro[indole-3,5′-isoxazoles] in a diastereomerically pure form. Several of these spirocyclic molecules exhibit promising anticancer activity by reducing viability and inducing differentiation of neuroblastoma cells 2019-06-25T12:20:31Z 2019-06-25T12:20:31Z 2019 Статья Aksenov, A.V., Aksenov, D.A., Arutiunov, N.A., Aksenov, N.A., Aleksandrova, E.V., Zhao, Z., Du, L., Kornienko, A., Rubin, M. Synthesis of Spiro[indole-3,5′-isoxazoles] with Anticancer Activity via a Formal [4 + 1]-Spirocyclization of Nitroalkenes to Indoles // Journal of Organic Chemistry. - 2019. - Volume 84. - Issue 11. - Pages 7123-7137 https://www.scopus.com/record/display.uri?eid=2-s2.0-85067007191&origin=resultslist&sort=plf-f&src=s&st1=Synthesis+of+Spiro%5bindole-3%2c5%E2%80%B2-isoxazoles%5d+with+Anticancer+Activity+via+a+Formal+%5b4+%2b+1%5d-Spirocyclization+of+Nitroalkenes+to+Indoles&st2=&sid=0a6da1faec8406656ad1e7a9ab6c75b0&sot=b&sdt=b&sl=147&s=TITLE-ABS-KEY%28Synthesis+of+Spiro%5bindole-3%2c5%E2%80%B2-isoxazoles%5d+with+Anticancer+Activity+via+a+Formal+%5b4+%2b+1%5d-Spirocyclization+of+Nitroalkenes+to+Indoles%29&relpos=0&citeCnt=0&searchTerm= http://hdl.handle.net/20.500.12258/5582 en Journal of Organic Chemistry application/pdf application/pdf American Chemical Society
institution	СКФУ
collection	Репозиторий
language	English
topic	Anticancer activity Indoles Nitroalkenes Spirocyclization
spellingShingle	Anticancer activity Indoles Nitroalkenes Spirocyclization Aksenov, A. V. Аксенов, А. В. Aksenov, D. A. Аксенов, Д. А. Arutiunov, N. A. Арутюнов, Н. А. Aksenov, N. A. Аксенов, Н. А. Aleksandrova, E. V. Александрова, Е. В. Rubin, M. A. Рубин, М. А. Synthesis of spiro[indole-3,5′-isoxazoles] with anticancer activity via a formal [4 + 1]-spirocyclization of nitroalkenes to indoles
description	An acid-assisted [4 + 1]-cycloaddition of indoles with nitrostyrenes affords 4′H-spiro[indole-3,5′-isoxazoles] in a diastereomerically pure form. Several of these spirocyclic molecules exhibit promising anticancer activity by reducing viability and inducing differentiation of neuroblastoma cells
format	Статья
author	Aksenov, A. V. Аксенов, А. В. Aksenov, D. A. Аксенов, Д. А. Arutiunov, N. A. Арутюнов, Н. А. Aksenov, N. A. Аксенов, Н. А. Aleksandrova, E. V. Александрова, Е. В. Rubin, M. A. Рубин, М. А.
author_facet	Aksenov, A. V. Аксенов, А. В. Aksenov, D. A. Аксенов, Д. А. Arutiunov, N. A. Арутюнов, Н. А. Aksenov, N. A. Аксенов, Н. А. Aleksandrova, E. V. Александрова, Е. В. Rubin, M. A. Рубин, М. А.
author_sort	Aksenov, A. V.
title	Synthesis of spiro[indole-3,5′-isoxazoles] with anticancer activity via a formal [4 + 1]-spirocyclization of nitroalkenes to indoles
title_short	Synthesis of spiro[indole-3,5′-isoxazoles] with anticancer activity via a formal [4 + 1]-spirocyclization of nitroalkenes to indoles
title_full	Synthesis of spiro[indole-3,5′-isoxazoles] with anticancer activity via a formal [4 + 1]-spirocyclization of nitroalkenes to indoles
title_fullStr	Synthesis of spiro[indole-3,5′-isoxazoles] with anticancer activity via a formal [4 + 1]-spirocyclization of nitroalkenes to indoles
title_full_unstemmed	Synthesis of spiro[indole-3,5′-isoxazoles] with anticancer activity via a formal [4 + 1]-spirocyclization of nitroalkenes to indoles
title_sort	synthesis of spiro[indole-3,5′-isoxazoles] with anticancer activity via a formal [4 + 1]-spirocyclization of nitroalkenes to indoles
publisher	American Chemical Society
publishDate	2019
url	https://www.scopus.com/record/display.uri?eid=2-s2.0-85067007191&origin=resultslist&sort=plf-f&src=s&st1=Synthesis+of+Spiro%5bindole-3%2c5%E2%80%B2-isoxazoles%5d+with+Anticancer+Activity+via+a+Formal+%5b4+%2b+1%5d-Spirocyclization+of+Nitroalkenes+to+Indoles&st2=&sid=0a6da1faec8406656ad1e7a9ab6c75b0&sot=b&sdt=b&sl=147&s=TITLE-ABS-KEY%28Synthesis+of+Spiro%5bindole-3%2c5%E2%80%B2-isoxazoles%5d+with+Anticancer+Activity+via+a+Formal+%5b4+%2b+1%5d-Spirocyclization+of+Nitroalkenes+to+Indoles%29&relpos=0&citeCnt=0&searchTerm= https://dspace.ncfu.ru/handle/20.500.12258/5582
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Synthesis of spiro[indole-3,5′-isoxazoles] with anticancer activity via a formal [4 + 1]-spirocyclization of nitroalkenes to indoles

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