Synthesis of spiro[indole-3,5′-isoxazoles] with anticancer activity via a formal [4 + 1]-spirocyclization of nitroalkenes to indoles

Synthesis of spiro[indole-3,5′-isoxazoles] with anticancer activity via a formal [4 + 1]-spirocyclization of nitroalkenes to indoles

An acid-assisted [4 + 1]-cycloaddition of indoles with nitrostyrenes affords 4′H-spiro[indole-3,5′-isoxazoles] in a diastereomerically pure form. Several of these spirocyclic molecules exhibit promising anticancer activity by reducing viability and inducing differentiation of neuroblastoma cells

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Главные авторы:	Aksenov, A. V., Аксенов, А. В., Aksenov, D. A., Аксенов, Д. А., Arutiunov, N. A., Арутюнов, Н. А., Aksenov, N. A., Аксенов, Н. А., Aleksandrova, E. V., Александрова, Е. В., Rubin, M. A., Рубин, М. А.
Формат:	Статья
Язык:	English
Опубликовано:	American Chemical Society 2019
Темы:	Anticancer activity Indoles Nitroalkenes Spirocyclization
Online-ссылка:	https://dspace.ncfu.ru/handle/20.500.12258/5582
Метки:	Добавить метку Нет меток, Требуется 1-ая метка записи!

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