Synthesis of spiro[indole-3,5′-isoxazoles] with anticancer activity via a formal [4 + 1]-spirocyclization of nitroalkenes to indoles
An acid-assisted [4 + 1]-cycloaddition of indoles with nitrostyrenes affords 4′H-spiro[indole-3,5′-isoxazoles] in a diastereomerically pure form. Several of these spirocyclic molecules exhibit promising anticancer activity by reducing viability and inducing differentiation of neuroblastoma cells
में बचाया:
| मुख्य लेखकों: | , , , , , , , , , , , |
|---|---|
| स्वरूप: | Статья |
| भाषा: | English |
| प्रकाशित: |
American Chemical Society
2019
|
| विषय: | |
| ऑनलाइन पहुंच: | https://www.scopus.com/record/display.uri?eid=2-s2.0-85067007191&origin=resultslist&sort=plf-f&src=s&st1=Synthesis+of+Spiro%5bindole-3%2c5%E2%80%B2-isoxazoles%5d+with+Anticancer+Activity+via+a+Formal+%5b4+%2b+1%5d-Spirocyclization+of+Nitroalkenes+to+Indoles&st2=&sid=0a6da1faec8406656ad1e7a9ab6c75b0&sot=b&sdt=b&sl=147&s=TITLE-ABS-KEY%28Synthesis+of+Spiro%5bindole-3%2c5%E2%80%B2-isoxazoles%5d+with+Anticancer+Activity+via+a+Formal+%5b4+%2b+1%5d-Spirocyclization+of+Nitroalkenes+to+Indoles%29&relpos=0&citeCnt=0&searchTerm= https://dspace.ncfu.ru/handle/20.500.12258/5582 |
| टैग : |
टैग जोड़ें
कोई टैग नहीं, इस रिकॉर्ड को टैग करने वाले पहले व्यक्ति बनें!
|
इंटरनेट
https://www.scopus.com/record/display.uri?eid=2-s2.0-85067007191&origin=resultslist&sort=plf-f&src=s&st1=Synthesis+of+Spiro%5bindole-3%2c5%E2%80%B2-isoxazoles%5d+with+Anticancer+Activity+via+a+Formal+%5b4+%2b+1%5d-Spirocyclization+of+Nitroalkenes+to+Indoles&st2=&sid=0a6da1faec8406656ad1e7a9ab6c75b0&sot=b&sdt=b&sl=147&s=TITLE-ABS-KEY%28Synthesis+of+Spiro%5bindole-3%2c5%E2%80%B2-isoxazoles%5d+with+Anticancer+Activity+via+a+Formal+%5b4+%2b+1%5d-Spirocyclization+of+Nitroalkenes+to+Indoles%29&relpos=0&citeCnt=0&searchTerm=https://dspace.ncfu.ru/handle/20.500.12258/5582