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N-substituted 1H-pyrimidin-4-one derivatives possessing anxiolytic activity

N-substituted 1H-pyrimidin-4-one derivatives possessing anxiolytic activity

The logical framework approach was implemented for designing CNS-active N-substituted 1H-pyrimidin-4-ones. Formation energies of possible ligand—receptor complexes with D2-dopamine and GABAA Receptors were determined from molecular docking calculations. The results allowed the probability of psychot...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Manvelyan, E. A., Манвелян, Э. А.
Fformat: Статья
Iaith:English
Cyhoeddwyd: Springer New York LLC 2018
Pynciau:
Anxiolytic activity
D2-dopamine and GABAA receptors
Molecular design
Pyrimidin-4-ones
Targeted synthesis
Mynediad Ar-lein:https://www.scopus.com/record/display.uri?eid=2-s2.0-85029121020&origin=resultslist&sort=plf-f&src=s&nlo=1&nlr=20&nls=afprfnm-t&affilName=nort*+caucas*+fed*+univ*&sid=1946c417b781d61d9cf2ec314093a48c&sot=afnl&sdt=cl&cluster=scopubyr%2c%222017%22%2ct&sl=53&s=%28AF-ID%28%22North+Caucasus+Federal+University%22+60070541%29%29&relpos=37&citeCnt=0&searchTerm=
https://dspace.ncfu.ru:443/handle/20.500.12258/692
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https://www.scopus.com/record/display.uri?eid=2-s2.0-85029121020&origin=resultslist&sort=plf-f&src=s&nlo=1&nlr=20&nls=afprfnm-t&affilName=nort*+caucas*+fed*+univ*&sid=1946c417b781d61d9cf2ec314093a48c&sot=afnl&sdt=cl&cluster=scopubyr%2c%222017%22%2ct&sl=53&s=%28AF-ID%28%22North+Caucasus+Federal+University%22+60070541%29%29&relpos=37&citeCnt=0&searchTerm=
https://dspace.ncfu.ru:443/handle/20.500.12258/692

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