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Synthesis of spiro[indole-3,5′-isoxazoles] with anticancer activity via a formal [4 + 1]-spirocyclization of nitroalkenes to indoles

Synthesis of spiro[indole-3,5′-isoxazoles] with anticancer activity via a formal [4 + 1]-spirocyclization of nitroalkenes to indoles

An acid-assisted [4 + 1]-cycloaddition of indoles with nitrostyrenes affords 4′H-spiro[indole-3,5′-isoxazoles] in a diastereomerically pure form. Several of these spirocyclic molecules exhibit promising anticancer activity by reducing viability and inducing differentiation of neuroblastoma cells

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Aksenov, A. V., Аксенов, А. В., Aksenov, D. A., Аксенов, Д. А., Arutiunov, N. A., Арутюнов, Н. А., Aksenov, N. A., Аксенов, Н. А., Aleksandrova, E. V., Александрова, Е. В., Rubin, M. A., Рубин, М. А.
التنسيق: Статья
اللغة:English
منشور في: American Chemical Society 2019
الموضوعات:
Anticancer activity
Indoles
Nitroalkenes
Spirocyclization
الوصول للمادة أونلاين:https://www.scopus.com/record/display.uri?eid=2-s2.0-85067007191&origin=resultslist&sort=plf-f&src=s&st1=Synthesis+of+Spiro%5bindole-3%2c5%E2%80%B2-isoxazoles%5d+with+Anticancer+Activity+via+a+Formal+%5b4+%2b+1%5d-Spirocyclization+of+Nitroalkenes+to+Indoles&st2=&sid=0a6da1faec8406656ad1e7a9ab6c75b0&sot=b&sdt=b&sl=147&s=TITLE-ABS-KEY%28Synthesis+of+Spiro%5bindole-3%2c5%E2%80%B2-isoxazoles%5d+with+Anticancer+Activity+via+a+Formal+%5b4+%2b+1%5d-Spirocyclization+of+Nitroalkenes+to+Indoles%29&relpos=0&citeCnt=0&searchTerm=
https://dspace.ncfu.ru/handle/20.500.12258/5582
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